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8HFG

Cryo-EM structure of human norepinephrine transporter NET in the presence of dopamine in an inward-open state at resolution of 3.0 angstrom.

Summary for 8HFG
Entry DOI10.2210/pdb8hfg/pdb
Related8HFE 8HFF
EMDB information34718 34719 34720
DescriptorSodium-dependent noradrenaline transporter, L-DOPAMINE, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsnorepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight69728.36
Authors
Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2022-11-10, release date: 2024-05-15)
Primary citationTan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C.
Molecular basis for the reuptake and inhibition of human norepinephrine transporter
To Be Published,
Experimental method
ELECTRON MICROSCOPY (3 Å)
Structure validation

221051

PDB entries from 2024-06-12

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