8HFI
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom.
Summary for 8HFI
Entry DOI | 10.2210/pdb8hfi/pdb |
Related | 8HFE 8HFF 8HFG |
EMDB information | 34718 34719 34720 34721 |
Descriptor | Sodium-dependent noradrenaline transporter, 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | norepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 69688.38 |
Authors | |
Primary citation | Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published, |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
Download full validation report