8HFI
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent noradrenaline transporter | polymer | 617 | 69386.5 | 1 | UniProt (P23975) Pfam (PF00209) | Homo sapiens (human) | Norepinephrine transporter,NET,Solute carrier family 6 member 2 |
| 2 | B (A) | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE | non-polymer | 266.4 | 1 | Chemie (DSM) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 69386.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 301.8 | |
| All* | Total formula weight | 69688.4 |
