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PDB: 12 results

1YMM
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TCR/HLA-DR2b/MBP-peptide complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ...
Authors:Hahn, M, Nicholson, M.J, Pyrdol, J, Wucherpfennig, K.W.
Deposit date:2005-01-21
Release date:2005-05-03
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor.
NAT.IMMUNOL., 6, 2005
2BC4
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Crystal structure of HLA-DM
Descriptor: CHLORIDE ION, HLA class II histocompatibility antigen, DM alpha chain, ...
Authors:Nicholson, M.J, Moradi, B, Seth, N.P, Xing, X, Cuny, G.D, Stein, R.L, Wucherpfennig, K.W.
Deposit date:2005-10-18
Release date:2006-05-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Small molecules that enhance the catalytic efficiency of HLA-DM.
J.Immunol., 176, 2006
3PL6
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Structure of Autoimmune TCR Hy.1B11 in complex with HLA-DQ1 and MBP 85-99
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MBP peptide / T-cell receptor beta chain chimera, MHC class II HLA-DQ-alpha chain, ...
Authors:Sethi, D.K, Wucherpfennig, K.W.
Deposit date:2010-11-13
Release date:2010-12-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
J.Exp.Med., 208, 2011
1JK8
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Crystal structure of a human insulin peptide-HLA-DQ8 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ8, insulin B peptide
Authors:Lee, K.H, Wucherpfennig, K.W, Wiley, D.C.
Deposit date:2001-07-11
Release date:2001-08-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.
Nat.Immunol., 2, 2001
2L35
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Structure of the DAP12-NKG2C transmembrane heterotrimer
Descriptor: DAP12-NKG2C_TM, TYRO protein tyrosine kinase-binding protein
Authors:Call, M.E, Wucherpfennig, K.W, Chou, J.J.
Deposit date:2010-09-06
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structural basis for intramembrane assembly of an activating immunoreceptor complex.
Nat.Immunol., 11, 2010
4GBX
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Crystal structure of an immune complex at pH 6.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DM alpha chain, ...
Authors:Sethi, D.K, Pos, W, Wucherpfennig, K.W.
Deposit date:2012-07-28
Release date:2013-01-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection.
Cell(Cambridge,Mass.), 151, 2012
4GRL
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Crystal structure of a autoimmune TCR-MHC complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II antigen, ...
Authors:Sethi, D.K, Wucherpfennig, K.W.
Deposit date:2012-08-25
Release date:2013-11-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.
Nat Commun, 4, 2013
4MAY
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Crystal structure of an immune complex
Descriptor: HY.1B11 TCR alpha chain, MHC class II HLA-DQ-alpha chain, MHC class II antigen, ...
Authors:Sethi, D.K, Wucherpfennig, K.W.
Deposit date:2013-08-18
Release date:2013-10-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.
Nat Commun, 4, 2013
4FQX
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Crystal structure of HLA-DM bound to HLA-DR1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DM alpha chain, ...
Authors:Sethi, D.K, Pos, W, Wucherpfennig, K.W.
Deposit date:2012-06-25
Release date:2013-01-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection.
Cell(Cambridge,Mass.), 151, 2012
2K4F
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Mouse CD3epsilon Cytoplasmic Tail
Descriptor: T-cell surface glycoprotein CD3 epsilon chain
Authors:Xu, C, Call, M.E, Schwieters, C.D, Schnell, J.R, Gagnon, E.E, Wucherpfennig, K.W, Chou, J.J.
Deposit date:2008-06-07
Release date:2008-12-02
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3varepsilon Cytoplasmic Tyrosine-Based Motif.
Cell(Cambridge,Mass.), 135, 2008
2HAC
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Structure of Zeta-Zeta Transmembrane Dimer
Descriptor: T-cell surface glycoprotein CD3 zeta chain
Authors:Chou, J.J, Wucherpfennig, K.W, Schnell, J.R, Call, M.E.
Deposit date:2006-06-12
Release date:2006-10-31
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.
Cell(Cambridge,Mass.), 127, 2006
2L34
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Structure of the DAP12 transmembrane homodimer
Descriptor: TYRO protein tyrosine kinase-binding protein
Authors:Call, M.E, Wucherpfennig, K.W, Chou, J.J.
Deposit date:2010-09-06
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structural basis for intramembrane assembly of an activating immunoreceptor complex.
Nat.Immunol., 11, 2010

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