3GW5
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![BU of 3gw5 by Molmil](/molmil-images/mine/3gw5) | Crystal structure of human renin complexed with a novel inhibitor | Descriptor: | (3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, Z, McKeever, B.M. | Deposit date: | 2009-03-31 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg.Med.Chem.Lett., 19, 2009
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1ZWO
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![BU of 1zwo by Molmil](/molmil-images/mine/1zwo) | NMR structure of murine gamma-S crystallin | Descriptor: | Gamma crystallin S | Authors: | Wu, Z, Delaglio, F, Wyatt, K, Wistow, G, Bax, A. | Deposit date: | 2005-06-04 | Release date: | 2005-07-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR. Protein Sci., 14, 2005
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1ZWM
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![BU of 1zwm by Molmil](/molmil-images/mine/1zwm) | NMR structure of murine gamma-S crystallin | Descriptor: | Gamma crystallin S | Authors: | Wu, Z, Delaglio, F, Wyatt, K, Wistow, G, Bax, A. | Deposit date: | 2005-06-03 | Release date: | 2005-07-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR. Protein Sci., 14, 2005
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1NAJ
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![BU of 1naj by Molmil](/molmil-images/mine/1naj) | High resolution NMR Structure Of DNA Dodecamer Determined In Aqueous Dilute Liquid Crystalline Phase | Descriptor: | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3' | Authors: | Wu, Z, Delaglio, F, Tjandra, N, Zhurkin, V, Bax, A. | Deposit date: | 2002-11-27 | Release date: | 2003-07-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Overall structure and sugar dynamics of a DNA dodecamer from homo- and heteronuclear dipolar couplings and (31)P chemical shift anisotropy. J.Biomol.Nmr, 26, 2003
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3KM4
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![BU of 3km4 by Molmil](/molmil-images/mine/3km4) | Optimization of Orally Bioavailable Alkyl Amine Renin Inhibitors | Descriptor: | (3R)-3-[(1S)-4-(acetylamino)-1-(3-chlorophenyl)-1-hydroxybutyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wu, Z, McKeever, B.M. | Deposit date: | 2009-11-09 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Optimization of orally bioavailable alkyl amine renin inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3Q3T
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![BU of 3q3t by Molmil](/molmil-images/mine/3q3t) | Alkyl Amine Renin Inhibitors: Filling S1 from S3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Wu, Z, McKeever, B. | Deposit date: | 2010-12-22 | Release date: | 2011-08-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket. Bioorg.Med.Chem.Lett., 21, 2011
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3Q4B
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![BU of 3q4b by Molmil](/molmil-images/mine/3q4b) | Clinically Useful Alkyl Amine Renin Inhibitors | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Renin, ... | Authors: | Wu, Z, McKeever, B.M. | Deposit date: | 2010-12-23 | Release date: | 2011-11-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. ACS Med Chem Lett, 2, 2011
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3Q5H
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![BU of 3q5h by Molmil](/molmil-images/mine/3q5h) | Clinically Useful Alkyl Amine Renin Inhibitors | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Renin, ... | Authors: | Wu, Z, McKeever, B.M. | Deposit date: | 2010-12-28 | Release date: | 2011-11-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility. ACS Med Chem Lett, 2, 2011
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3K2S
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![BU of 3k2s by Molmil](/molmil-images/mine/3k2s) | Solution structure of double super helix model | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Apolipoprotein A-I, CHOLESTEROL | Authors: | Wu, Z, Gogonea, V, Lee, X, Wagner, M.A, Li, X.-M, Huang, Y, Undurti, A, May, R.P, Haertlein, M, Moulin, M, Gutsche, I, Zaccai, G, Didonato, J.A, Hazen, L.S. | Deposit date: | 2009-09-30 | Release date: | 2010-04-07 | Last modified: | 2024-02-21 | Method: | SOLUTION SCATTERING | Cite: | Double superhelix model of high density lipoprotein. J.Biol.Chem., 284, 2009
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2NRF
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![BU of 2nrf by Molmil](/molmil-images/mine/2nrf) | Crystal Structure of GlpG, a Rhomboid family intramembrane protease | Descriptor: | Protein GlpG | Authors: | Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y. | Deposit date: | 2006-11-02 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat.Struct.Mol.Biol., 13, 2006
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7XOE
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![BU of 7xoe by Molmil](/molmil-images/mine/7xoe) | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide | Authors: | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | Deposit date: | 2022-05-01 | Release date: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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7XOG
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![BU of 7xog by Molmil](/molmil-images/mine/7xog) | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Postfusion state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide, ... | Authors: | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | Deposit date: | 2022-05-01 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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7WJU
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![BU of 7wju by Molmil](/molmil-images/mine/7wju) | Cryo-EM structure of the AsCas12f1-sgRNAv1-dsDNA ternary complex | Descriptor: | Non-target strand, OrfB_Zn_ribbon domain-containing protein, Target strand, ... | Authors: | Wu, Z, Liu, D, Shen, H, Ji, Q. | Deposit date: | 2022-01-07 | Release date: | 2023-01-18 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Structure-directed functional evolution of the miniature CRISPR-AsCas12f1 system To Be Published
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1K6U
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![BU of 1k6u by Molmil](/molmil-images/mine/1k6u) | Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor | Descriptor: | 1,2-ETHANEDIOL, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION | Authors: | Botos, I, Wu, Z, Lu, W, Wlodawer, A. | Deposit date: | 2001-10-17 | Release date: | 2001-12-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor. FEBS Lett., 509, 2001
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1YOP
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![BU of 1yop by Molmil](/molmil-images/mine/1yop) | The solution structure of Kti11p | Descriptor: | Kti11p, ZINC ION | Authors: | Sun, J, Zhang, J, Wu, F, Xu, C, Li, S, Zhao, W, Wu, Z, Wu, J, Zhou, C.-Z, Shi, Y. | Deposit date: | 2005-01-28 | Release date: | 2005-04-05 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module. Biochemistry, 44, 2005
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1ZXT
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![BU of 1zxt by Molmil](/molmil-images/mine/1zxt) | Crystal Structure of A Viral Chemokine | Descriptor: | functional macrophage inflammatory protein 1-alpha homolog | Authors: | Luz, J.G, Yu, M, Su, Y, Wu, Z, Zhou, Z, Sun, R, Wilson, I.A. | Deposit date: | 2005-06-08 | Release date: | 2005-08-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A. J.Mol.Biol., 352, 2005
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6IGM
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![BU of 6igm by Molmil](/molmil-images/mine/6igm) | Cryo-EM Structure of Human SRCAP Complex | Descriptor: | Actin-related protein 6, Helicase SRCAP, RuvB-like 1, ... | Authors: | Feng, Y, Tian, Y, Wu, Z, Xu, Y. | Deposit date: | 2018-09-25 | Release date: | 2019-07-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of human SRCAP complex. Cell Res., 28, 2018
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1QBQ
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![BU of 1qbq by Molmil](/molmil-images/mine/1qbq) | STRUCTURE OF RAT FARNESYL PROTEIN TRANSFERASE COMPLEXED WITH A CVIM PEPTIDE AND ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID. | Descriptor: | ACETATE ION, ACETYL-CYS-VAL-ILE-SELENOMET-COOH PEPTIDE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, ... | Authors: | Strickland, C.L, Windsor, W.T, Syto, R, Wang, L, Bond, R, Wu, Z, Schwartz, J, Le, H.V, Beese, L.S, Weber, P.C. | Deposit date: | 1999-04-27 | Release date: | 1999-06-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue Biochemistry, 37, 1998
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3B4R
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![BU of 3b4r by Molmil](/molmil-images/mine/3b4r) | Site-2 Protease from Methanocaldococcus jannaschii | Descriptor: | Putative zinc metalloprotease MJ0392, ZINC ION | Authors: | Jeffrey, P.D, Feng, L, Yan, H, Wu, Z, Yan, N, Wang, Z, Shi, Y. | Deposit date: | 2007-10-24 | Release date: | 2008-01-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of a site-2 protease family intramembrane metalloprotease. Science, 318, 2007
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5B7W
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1N8X
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![BU of 1n8x by Molmil](/molmil-images/mine/1n8x) | Solution structure of HIV-1 Stem Loop SL1 | Descriptor: | HIV-1 STEM LOOP SL1 MONOMERIC RNA | Authors: | Lawrence, D.C, Stover, C.C, Noznitsky, J, Wu, Z, Summers, M.F. | Deposit date: | 2002-11-21 | Release date: | 2003-04-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the Intact Stem and Bulge of HIV-1 Psi-RNA Stem-Loop SL1 J.Mol.Biol., 326, 2003
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2OZ7
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![BU of 2oz7 by Molmil](/molmil-images/mine/2oz7) | Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate | Descriptor: | Androgen receptor, CYPROTERONE ACETATE | Authors: | Bohl, C.E, Wu, Z, Miller, D.D, Bell, C.E, Dalton, J.T. | Deposit date: | 2007-02-25 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. J.Biol.Chem., 282, 2007
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3IR1
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![BU of 3ir1 by Molmil](/molmil-images/mine/3ir1) | Crystal Structure of Lipoprotein GNA1946 from Neisseria meningitidis | Descriptor: | METHIONINE, Outer membrane lipoprotein GNA1946, SULFATE ION | Authors: | Yang, X, Wu, Z, Wang, X, Shen, Y. | Deposit date: | 2009-08-21 | Release date: | 2009-10-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structure of lipoprotein GNA1946 from Neisseria meningitidis J.Struct.Biol., 168, 2009
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5VTO
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![BU of 5vto by Molmil](/molmil-images/mine/5vto) | |
3QZR
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![BU of 3qzr by Molmil](/molmil-images/mine/3qzr) | Human enterovirus 71 3C protease mutant E71A in complex with rupintrivir | Descriptor: | 1,2-ETHANEDIOL, 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | Authors: | Wang, J, Fan, T, Yao, X, Wu, Z, Guo, L, Lei, X, Wang, J, Wang, M, Jin, Q, Cui, S. | Deposit date: | 2011-03-07 | Release date: | 2011-08-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.039 Å) | Cite: | Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues. J.Virol., 85, 2011
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