2OZ7
Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate
Summary for 2OZ7
| Entry DOI | 10.2210/pdb2oz7/pdb |
| Related | 1i38 1z95 2ax6 2ax7 2axa |
| Descriptor | Androgen receptor, CYPROTERONE ACETATE (3 entities in total) |
| Functional Keywords | androgen receptor, anti-androgen, prostate cancer, hormone receptor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: P10275 |
| Total number of polymer chains | 1 |
| Total formula weight | 29432.99 |
| Authors | Bohl, C.E.,Wu, Z.,Miller, D.D.,Bell, C.E.,Dalton, J.T. (deposition date: 2007-02-25, release date: 2007-03-27, Last modification date: 2023-08-30) |
| Primary citation | Bohl, C.E.,Wu, Z.,Miller, D.D.,Bell, C.E.,Dalton, J.T. Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. J.Biol.Chem., 282:13648-13655, 2007 Cited by PubMed: 17311914DOI: 10.1074/jbc.M611711200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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