6MG9
 
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9FGP
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6OB6
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6OB7
 | | Human equilibrative nucleoside transporter-1, dilazep bound | | Descriptor: | (1,4-diazepane-1,4-diyl)di(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate), (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Equilibrative nucleoside transporter 1 | | Authors: | Wright, N.J, Lee, S.-Y. | | Deposit date: | 2019-03-19 | | Release date: | 2019-07-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of human ENT1 in complex with adenosine reuptake inhibitors.
Nat.Struct.Mol.Biol., 26, 2019
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8TZI
 | | Human equilibrative nucleoside transporter-1, JH-ENT-01 bound | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[4-[3-[3,4-dimethoxy-5-[[4-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]methoxy]phenyl]carbonyloxypropyl]-1,4-diazepan-1-yl]propyl 3,4,5-trimethoxybenzoate, Equilibrative nucleoside transporter 1 | | Authors: | Wright, N.J, Lee, S.Y. | | Deposit date: | 2023-08-26 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Rational ENT1 inhibition as a pathway for neuropathic pain relief
To Be Published
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7TX7
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7TX6
 | | Cryo-EM structure of the human reduced folate carrier in complex with methotrexate | | Descriptor: | Digitonin, METHOTREXATE, Reduced folate transporter,Soluble cytochrome b562 | | Authors: | Wright, N.J, Fedor, J.G, Lee, S.-Y. | | Deposit date: | 2022-02-07 | | Release date: | 2022-09-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
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8DEP
 | | Cryo-EM structure of the human reduced folate carrier, apo condition | | Descriptor: | Digitonin, Reduced folate transporter,Soluble cytochrome b562 | | Authors: | Wright, N.J, Fedor, J.G, Lee, S.-Y. | | Deposit date: | 2022-06-21 | | Release date: | 2022-09-21 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
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4RSV
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8QKR
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.251 | | Descriptor: | R5251VHCH, R5251VLCL, Reticulocyte-binding protein-like protein 5 | | Authors: | Wright, N.D, Barrett, J.R, Bradshaw, W.J, Paterson, N.G, MacLean, E.M, Ferreira, L, McHugh, K, Koekemoer, L, Draper, S.J. | | Deposit date: | 2023-09-16 | | Release date: | 2024-07-31 | | Last modified: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (3.234 Å) | | Cite: | Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype.
Cell, 187, 2024
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8TZ4
 | | Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, subset reconstruction | | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile, Sodium/nucleoside cotransporter | | Authors: | Wright, N.J, Lee, S.-Y. | | Deposit date: | 2023-08-26 | | Release date: | 2024-03-13 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 20, 2024
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8TZ2
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8TZD
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8TZ1
 | | Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Ribavirin | | Descriptor: | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, ... | | Authors: | Wright, N.J, Lee, S.-Y. | | Deposit date: | 2023-08-26 | | Release date: | 2024-03-13 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 20, 2024
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8TZ7
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8TZ6
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8TZA
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8TZ3
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8TZ8
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8TZ9
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8QKS
 | | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to R5.034 | | Descriptor: | Immunoglobulin lambda variable 1-36, R5034HV, Reticulocyte-binding protein-like protein 5 | | Authors: | Wright, N.D, Barrett, J.R, Bradshaw, W.J, Paterson, N.G, MacLean, E.M, Ferreira, L, McHugh, K, Von Delft, F, Koekemoer, L, Draper, S.J. | | Deposit date: | 2023-09-16 | | Release date: | 2024-07-31 | | Last modified: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (3.994 Å) | | Cite: | Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype.
Cell, 187, 2024
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8TZ5
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6DL4
 | | Human Titin ZIg10 | | Descriptor: | Titin | | Authors: | Wright, N.T. | | Deposit date: | 2018-05-31 | | Release date: | 2019-08-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural Insights on the Obscurin-Binding Domains in Titin.
Protein Pept.Lett., 25, 2018
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2K2F
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2MWC
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