6DL4

Human Titin ZIg10

Summary for 6DL4

• Entry DOI: 10.2210/pdb6dl4/pdb
• NMR Information: BMRB: 30471
• Descriptor: Titin (1 entity in total)
• Functional Keywords: titin, sarcomere, cytoskeleton, structural protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13965.90

Authors

Wright, N.T. (deposition date: 2018-05-31, release date: 2019-08-21, Last modification date: 2024-05-01)

Primary citation

Letourneau, A.G.,Wright, N.T.
Structural Insights on the Obscurin-Binding Domains in Titin.
Protein Pept.Lett., 25:973-979, 2018

PubMed Abstract: The giant muscular proteins titin and obscurin bind to each other at the Zdisk during muscle development. This binding event is mediated through two domains from each protein: ZIg9/10 from titin and Ig58/59 from obscurin. This interaction helps stabilize and organize the sarcomere; ablation of this binding leads to muscular dystrophy.

PubMed: 30289063
DOI: 10.2174/0929866525666181004102031

Experimental method

SOLUTION NMR