4IQ8
| Crystal structure of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae | 分子名称: | Glyceraldehyde-3-phosphate dehydrogenase 3 | 著者 | Wang, H, Liu, Q, Niu, L, Teng, M, Li, X. | 登録日 | 2013-01-11 | 公開日 | 2013-02-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Preliminary crystallographic analysis of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae. Acta Crystallogr.,Sect.F, 68, 2012
|
|
2ZUL
| Crystal structure of Thermus thermophilus 16S rRNA methyltransferase RsmC (TTHA0533) in complex with cofactor S-adenosyl-L-Methionine | 分子名称: | Probable ribosomal RNA small subunit methyltransferase, S-ADENOSYLMETHIONINE | 著者 | Wang, H, Kawazoe, M, Tatsuguchi, A, Naoe, C, Takemoto, C, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2008-10-21 | 公開日 | 2009-10-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of Thermus thermophilus 16S rRNA methyltransferase RsmC (TTHA0533) in complex with cofactor S-adenosyl-L-Methionine To be Published
|
|
2YV5
| Crystal structure of Yjeq from Aquifex aeolicus | 分子名称: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, YjeQ protein, ... | 著者 | Wang, H, Kaminishi, T, Hanawa-Suetsugu, K, Takemoto, C, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-09 | 公開日 | 2008-04-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of YjeQ from Aquifex aeolicus To be Published
|
|
2H42
| Crystal structure of PDE5 in complex with sildenafil | 分子名称: | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, MAGNESIUM ION, ZINC ION, ... | 著者 | Wang, H, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
5B6O
| Crystal structure of MS8104 | 分子名称: | 3C-like proteinase | 著者 | Wang, H, Kim, Y, Muramatsu, T, Takemoto, C, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2016-05-31 | 公開日 | 2016-06-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
2H44
| Crystal structure of PDE5A1 in complex with icarisid II | 分子名称: | 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE, MAGNESIUM ION, ZINC ION, ... | 著者 | Wang, H, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
2H40
| Crystal structure of the catalytic domain of unliganded PDE5 | 分子名称: | MAGNESIUM ION, ZINC ION, cGMP-specific 3',5'-cyclic phosphodiesterase | 著者 | Wang, H, Liu, Y, Huai, Q, Cai, J, Zoraghi, R, Francis, S.H, Corbin, J.D, Robinson, H, Xin, Z, Lin, G, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
2ZWV
| Crystal structure of Thermus thermophilus 16S rRNA methyltransferase RsmC (TTHA0533) | 分子名称: | Probable ribosomal RNA small subunit methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Wang, H, Kawazoe, M, Kaminishi, T, Tatsuguchi, A, Naoe, C, Terada, T, Shirouzu, M, Takemoto, C, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2008-12-18 | 公開日 | 2009-12-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Thermus thermophilus 16S rRNA methyltransferase RsmC (TTHA0533) to be published
|
|
8HEI
| Crystal structure of CTSB in complex with E64d | 分子名称: | Cathepsin B, GLYCEROL, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate | 著者 | Wang, H, Li, D, Sun, L, Yang, H. | 登録日 | 2022-11-08 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
|
|
8HET
| Crystal structure of CTSL in complex with E64d | 分子名称: | Procathepsin L, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate | 著者 | Wang, H, Shao, M, Sun, L, Yang, H. | 登録日 | 2022-11-08 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
|
|
8HE9
| Crystal structure of CTSB in complex with K777 | 分子名称: | Cathepsin B, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Wang, H, Li, D, Sun, L, Yang, H. | 登録日 | 2022-11-07 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
|
|
8HEN
| Crystal structure of CTSB in complex with 212-148 | 分子名称: | 2-[4-[[(2~{S})-1-oxidanylidene-3-phenyl-1-[[(3~{S})-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]amino]propan-2-yl]carbamoyl]piperazin-1-yl]ethyl 4-carbamimidamidobenzoate, Cathepsin B, DIMETHYL SULFOXIDE, ... | 著者 | Wang, H, Li, D, Sun, L, Yang, H. | 登録日 | 2022-11-08 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nat Commun, 14, 2023
|
|
4HN2
| Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMPPNP and a substrate analog 5PA-IP5 | 分子名称: | (2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}ethyl)phosphonic acid, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, MAGNESIUM ION, ... | 著者 | Wang, H. | 登録日 | 2012-10-18 | 公開日 | 2012-10-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP(5) kinase. Chem.Commun.(Camb.), 48, 2012
|
|
4Q4D
| Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and synthetic 3,5-(PP)2-IP4 (3,5-IP8) | 分子名称: | (1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, MAGNESIUM ION, ... | 著者 | Wang, H, Shears, S.B. | 登録日 | 2014-04-14 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
3FG7
| |
6K8N
| Crystal structure of the Sulfolobus solfataricus topoisomerase III | 分子名称: | ZINC ION, topoisomerase III | 著者 | Wang, H.Q, Zhang, J.H, Zheng, X, Zheng, Z.F, Dong, Y.H, Huang, L, Gong, Y. | 登録日 | 2019-06-13 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain To Be Published
|
|
6K8O
| Crystal structure of the Sulfolobus solfataricus topoisomerase III in complex with DNA | 分子名称: | DNA (5'-D(*GP*CP*AP*AP*GP*GP*TP*C)-3'), ZINC ION, topoisomerase III | 著者 | Wang, H.Q, Zhang, J.H, Zheng, X, Zheng, Z.F, Dong, Y.H, Huang, L, Gong, Y. | 登録日 | 2019-06-13 | 公開日 | 2020-06-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain To Be Published
|
|
2PW3
| Structure of the PDE4D-cAMP complex | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 著者 | Wang, H, Robinson, H, Ke, H. | 登録日 | 2007-05-10 | 公開日 | 2007-10-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. J.Mol.Biol., 371, 2007
|
|
6BYF
| |
4NND
| |
4GAZ
| Crystal Structure of a Jumonji Domain-containing Protein JMJD5 | 分子名称: | Lysine-specific demethylase 8, N-OXALYLGLYCINE, NICKEL (II) ION | 著者 | Wang, H, Zhou, X, Zhang, X, Tao, Y, Chen, N, Zang, J. | 登録日 | 2012-07-26 | 公開日 | 2013-08-14 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Crystal Structure of a Jumonji Domain-containing Protein JMJD5 To be Published
|
|
5F18
| Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1 | 分子名称: | Niemann-Pick C1 protein | 著者 | Wang, H, Shi, Y, Song, J, Qi, J, Lu, G, Yan, J, Gao, G.F. | 登録日 | 2015-11-30 | 公開日 | 2016-01-20 | 最終更新日 | 2016-01-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1. Cell, 164, 2016
|
|
5YS5
| Crystal structure of Multicopper Oxidase CueO G304K mutant with seven copper ions | 分子名称: | Blue copper oxidase CueO, COPPER (II) ION | 著者 | Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y. | 登録日 | 2017-11-13 | 公開日 | 2018-10-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity Sci Rep, 8, 2018
|
|
6HBB
| Crystal Structure of the small subunit-like domain 1 of CcmM from Synechococcus elongatus (strain PCC 7942) | 分子名称: | Carbon dioxide concentrating mechanism protein CcmM, SULFATE ION | 著者 | Wang, H, Yan, X, Aigner, H, Bracher, A, Nguyen, N.D, Hee, W.Y, Long, B.M, Price, G.D, Hartl, F.U, Hayer-Hartl, M. | 登録日 | 2018-08-10 | 公開日 | 2018-12-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Rubisco condensate formation by CcmM in beta-carboxysome biogenesis. Nature, 566, 2019
|
|
5F1B
| Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GP1, GP2, ... | 著者 | Wang, H, Shi, Y, Song, J, Qi, J, Lu, G, Yan, J, Gao, G.F. | 登録日 | 2015-11-30 | 公開日 | 2016-01-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1. Cell, 164, 2016
|
|