8HEI

Crystal structure of CTSB in complex with E64d

Summary for 8HEI

• Entry DOI: 10.2210/pdb8hei/pdb
• Descriptor: Cathepsin B, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: inhibitor, antiviral, protease, antiviral protein, antiviral protein-inhibitor complex, antiviral protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 28821.13

Authors

Wang, H.,Li, D.,Sun, L.,Yang, H. (deposition date: 2022-11-08, release date: 2023-12-13, Last modification date: 2024-06-19)

• Primary citation: Wang, H.,Yang, Q.,Liu, X.,Xu, Z.,Shao, M.,Li, D.,Duan, Y.,Tang, J.,Yu, X.,Zhang, Y.,Hao, A.,Wang, Y.,Chen, J.,Zhu, C.,Guddat, L.,Chen, H.,Zhang, L.,Chen, X.,Jiang, B.,Sun, L.,Rao, Z.,Yang, H.; Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.; Nat Commun, 14:7574-7574, 2023; PubMed: 37990007; DOI: 10.1038/s41467-023-42527-5

Experimental method

X-RAY DIFFRACTION (1.55 Å)