4Q4D

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and synthetic 3,5-(PP)2-IP4 (3,5-IP8)

Summary for 4Q4D

Entry DOI	10.2210/pdb4q4d/pdb
Related	4Q4C
Descriptor	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], ... (5 entities in total)
Functional Keywords	kinase, synthesis, inositol pyrophosphate, enantiomer, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol: O43314
Total number of polymer chains	1
Total formula weight	38968.00
Authors	Wang, H.,Shears, S.B. (deposition date: 2014-04-14, release date: 2014-08-06, Last modification date: 2023-09-20)
Primary citation	Capolicchio, S.,Wang, H.,Thakor, D.T.,Shears, S.B.,Jessen, H.J. Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew.Chem.Int.Ed.Engl., 53:9508-9511, 2014 Cited by PubMed: 25044992 DOI: 10.1002/anie.201404398 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation