4Q4D
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and synthetic 3,5-(PP)2-IP4 (3,5-IP8)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | polymer | 330 | 37568.9 | 1 | UniProt (O43314) Pfam (PF18086) In PDB | Homo sapiens (human) | Diphosphoinositol pentakisphosphate kinase 2, Histidine acid phosphatase domain-containing protein 1, InsP6 and PP-IP5 kinase 2, VIP1 homolog 2, hsVIP2 |
| 2 | A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | A | (1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] | non-polymer | 820.0 | 1 | Chemie (2YN) | |||
| 4 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | water | water | 18.0 | 403 | Chemie (HOH) |
Sequence modifications
A: 41 - 366 (UniProt: O43314)
| PDB | External Database | Details |
|---|---|---|
| Gly 37 | - | expression tag |
| Ser 38 | - | expression tag |
| Phe 39 | - | expression tag |
| Thr 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37568.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1399.1 | |
| All* | Total formula weight | 38968.0 |
