4WXV
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![BU of 4wxv by Molmil](/molmil-images/mine/4wxv) | Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI) | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | 著者 | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | 登録日 | 2014-11-14 | 公開日 | 2015-07-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates. J.Biol.Chem., 290, 2015
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7OXN
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![BU of 7oxn by Molmil](/molmil-images/mine/7oxn) | Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta precursor protein, TAP01 family antibody heavy chain, ... | 著者 | Hall, G, Cowan, R, Carr, M.D. | 登録日 | 2021-06-22 | 公開日 | 2022-06-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease. Mol Psychiatry, 27, 2022
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7OW1
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![BU of 7ow1 by Molmil](/molmil-images/mine/7ow1) | Crystal Structure of TAP01 in complex with amyloid beta peptide | 分子名称: | Amyloid-beta precursor protein, CITRATE ANION, TAP01 family antibody heavy chain, ... | 著者 | Hall, G, Cowan, R, Carr, M.D. | 登録日 | 2021-06-16 | 公開日 | 2022-06-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease. Mol Psychiatry, 27, 2022
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6JYV
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![BU of 6jyv by Molmil](/molmil-images/mine/6jyv) | Structure of an isopenicillin N synthase from Pseudomonas aeruginosa PAO1 | 分子名称: | Probable iron/ascorbate oxidoreductase, SODIUM ION | 著者 | Hao, Z, Che, S, Wang, R, Liu, R, Zhang, Q, Bartlam, M. | 登録日 | 2019-04-28 | 公開日 | 2019-05-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | Structural characterization of an isopenicillin N synthase family oxygenase from Pseudomonas aeruginosa PAO1. Biochem.Biophys.Res.Commun., 514, 2019
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5GT9
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![BU of 5gt9 by Molmil](/molmil-images/mine/5gt9) | The X-ray structure of 7beta-hydroxysteroid dehydrogenase | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, short chain dehydrogenase/reductase family protein | 著者 | Wang, F, Wang, R, Lv, Z, Chen, Q, Huo, X. | 登録日 | 2016-08-19 | 公開日 | 2017-05-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of NADP(+)-bound 7 beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes Acta Crystallogr F Struct Biol Commun, 73, 2017
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3VFE
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![BU of 3vfe by Molmil](/molmil-images/mine/3vfe) | Virtual Screening and X-Ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group | 分子名称: | 4-{[(3R)-3-{[(7-methoxynaphthalen-2-yl)sulfonyl](thiophen-3-ylmethyl)amino}-2-oxopyrrolidin-1-yl]methyl}thiophene-2-carboximidamide, Kallikrein-6 | 著者 | Chen, X, Zhang, Y, Xia, T, Wang, R. | 登録日 | 2012-01-09 | 公開日 | 2012-11-21 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group. Acs Med.Chem.Lett., 3, 2012
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1BBY
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![BU of 1bby by Molmil](/molmil-images/mine/1bby) | DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, MINIMIZED AVERAGE | 分子名称: | RAP30 | 著者 | Groft, C.M, Uljon, S.N, Wang, R, Werner, M.H. | 登録日 | 1998-04-26 | 公開日 | 1998-11-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly. Proc.Natl.Acad.Sci.USA, 95, 1998
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4ZA1
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![BU of 4za1 by Molmil](/molmil-images/mine/4za1) | Crystal Structure of NosA Involved in Nosiheptide Biosynthesis | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, NosA | 著者 | Liu, S, Guo, H, Zhang, T, Han, L, Yao, P, Zhang, Y, Rong, N, Yu, Y, Lan, W, Wang, C, Ding, J, Wang, R, Liu, W, Cao, C. | 登録日 | 2015-04-13 | 公開日 | 2015-08-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis Sci Rep, 5, 2015
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6JJP
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![BU of 6jjp by Molmil](/molmil-images/mine/6jjp) | Crystal structure of Fab of a PD-1 monoclonal antibody MW11-h317 in complex with PD-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of MW11-h317, Programmed cell death protein 1, ... | 著者 | Wang, M, Wang, J, Wang, R, Jiao, S, Wang, S, Zhang, J, Zhang, M. | 登録日 | 2019-02-26 | 公開日 | 2019-10-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Identification of a monoclonal antibody that targets PD-1 in a manner requiring PD-1 Asn58 glycosylation. Commun Biol, 2, 2019
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4DQM
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![BU of 4dqm by Molmil](/molmil-images/mine/4dqm) | Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity | 分子名称: | (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, Nuclear receptor coactivator 1, Retinoic acid receptor alpha | 著者 | Wang, S, Wang, Z, Lin, S, Zheng, W, Wang, R, Jin, S, Chen, J, Jin, L, Li, Y. | 登録日 | 2012-02-16 | 公開日 | 2012-10-03 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem.J., 446, 2012
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7DK2
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![BU of 7dk2 by Molmil](/molmil-images/mine/7dk2) | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MW07 heavy chain, MW07 light chain, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M, Chen, S. | 登録日 | 2020-11-22 | 公開日 | 2021-12-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Architectural versatility of spike neutralization by a SARS-CoV-2 antibody To Be Published
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5JBT
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![BU of 5jbt by Molmil](/molmil-images/mine/5jbt) | Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2) | 分子名称: | Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ... | 著者 | Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S. | 登録日 | 2016-04-13 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis. J. Biol. Chem., 291, 2016
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3I4H
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![BU of 3i4h by Molmil](/molmil-images/mine/3i4h) | Crystal structure of Cas6 in Pyrococcus furiosus | 分子名称: | endoribonuclease | 著者 | Carte, J, Wang, R, Li, H, Terns, R.M, Terns, M.P. | 登録日 | 2009-07-01 | 公開日 | 2009-09-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes Genes Dev., 22, 2008
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5FB8
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![BU of 5fb8 by Molmil](/molmil-images/mine/5fb8) | Structure of Interleukin-16 bound to the 14.1 antibody | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-IL-16 antibody 14.1 Fab domain Heavy Chain, ... | 著者 | Hall, G, Cowan, R, Bayliss, R, Carr, M. | 登録日 | 2015-12-14 | 公開日 | 2016-06-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES. J.Biol.Chem., 291, 2016
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2BBY
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![BU of 2bby by Molmil](/molmil-images/mine/2bby) | DNA-BINDING DOMAIN FROM HUMAN RAP30, NMR, 30 STRUCTURES | 分子名称: | RAP30 | 著者 | Groft, C.M, Uljon, S.N, Wang, R, Werner, M.H. | 登録日 | 1998-04-27 | 公開日 | 1998-11-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly. Proc.Natl.Acad.Sci.USA, 95, 1998
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7BNV
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![BU of 7bnv by Molmil](/molmil-images/mine/7bnv) | Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-300 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, Light Chain, ... | 著者 | Hall, G, Cowan, R, Carr, M. | 登録日 | 2021-01-22 | 公開日 | 2021-11-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses. Front Immunol, 12, 2021
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3V4U
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![BU of 3v4u by Molmil](/molmil-images/mine/3v4u) | Structure of a monoclonal antibody complexed with its MHC-I antigen | 分子名称: | ANTI-MHC-I MONOCLONAL ANTIBODY, 64-3-7 H CHAIN, 64-3-7 L CHAIN, ... | 著者 | Margulies, D.H, Mage, M.G, Wang, R, Natarajan, K. | 登録日 | 2011-12-15 | 公開日 | 2012-07-25 | 最終更新日 | 2012-08-01 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J.Immunol., 189, 2012
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3V52
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![BU of 3v52 by Molmil](/molmil-images/mine/3v52) | Structure of a monoclonal antibody complexed with its MHC-I antigen | 分子名称: | 1,2-ETHANEDIOL, ANTI-MHC-I MONOCLONAL ANTIBODY, 64-3-7 H CHAIN, ... | 著者 | Mage, M.G, Dolan, M.A, Wang, R, Boyd, L.F, Revilleza, M.J, Robinson, H, Natarajan, K, Myers, N.B, Hansen, T.H, Margulies, D.H. | 登録日 | 2011-12-15 | 公開日 | 2012-07-25 | 最終更新日 | 2012-08-01 | 実験手法 | X-RAY DIFFRACTION (1.697 Å) | 主引用文献 | The Peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J.Immunol., 189, 2012
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7DK0
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![BU of 7dk0 by Molmil](/molmil-images/mine/7dk0) | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW05 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MW05 heavy chain, MW05 light chain, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | 登録日 | 2020-11-22 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.199 Å) | 主引用文献 | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc gamma RIIB and virus-antibody complex with bivalent interaction. Commun Biol, 5, 2022
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7DJZ
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![BU of 7djz by Molmil](/molmil-images/mine/7djz) | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW01 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, MW01 heavy chain, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | 登録日 | 2020-11-22 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | 主引用文献 | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc gamma RIIB and virus-antibody complex with bivalent interaction. Commun Biol, 5, 2022
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7DPM
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![BU of 7dpm by Molmil](/molmil-images/mine/7dpm) | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | 登録日 | 2020-12-20 | 公開日 | 2021-02-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.304 Å) | 主引用文献 | Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV. Mabs, 13, 2021
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8APU
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![BU of 8apu by Molmil](/molmil-images/mine/8apu) | Crystal Structure of H. influenzae TrmD in complex with Compound 14 | 分子名称: | 6-[[4-(aminomethyl)phenyl]methylamino]pyridine-3-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | 著者 | Hall, G, Cowan, R, Carr, M.D. | 登録日 | 2022-08-10 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg.Med.Chem.Lett., 90, 2023
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8APT
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![BU of 8apt by Molmil](/molmil-images/mine/8apt) | Crystal Structure of H. influenzae TrmD in complex with Compound 13 | 分子名称: | 6-[[3-(aminomethyl)phenyl]methylamino]pyridine-3-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | 著者 | Hall, G, Cowan, R, Carr, M.D. | 登録日 | 2022-08-10 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg.Med.Chem.Lett., 90, 2023
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8APV
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![BU of 8apv by Molmil](/molmil-images/mine/8apv) | Crystal Structure of H. influenzae TrmD in complex with Compound 27 | 分子名称: | 1-[[4-(aminomethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-5-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | 著者 | Hall, G, Cowan, R, Carr, M.D. | 登録日 | 2022-08-10 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg.Med.Chem.Lett., 90, 2023
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8APW
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![BU of 8apw by Molmil](/molmil-images/mine/8apw) | Crystal Structure of H. influenzae TrmD in complex with Compound 30 | 分子名称: | 1-[2-oxidanylidene-2-(piperidin-4-ylamino)ethyl]pyrrolo[2,3-b]pyridine-5-carboxamide, CITRIC ACID, tRNA (guanine-N(1)-)-methyltransferase | 著者 | Hall, G, Cowan, R, Carr, M.D. | 登録日 | 2022-08-10 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. Bioorg.Med.Chem.Lett., 90, 2023
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