1MLW
| Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III) | 分子名称: | 7,8-DIHYDROBIOPTERIN, FE (III) ION, Tryptophan 5-monooxygenase | 著者 | Wang, L, Erlandsen, H, Haavik, J, Knappskog, P.M, Stevens, R.C. | 登録日 | 2002-08-31 | 公開日 | 2002-12-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry, 41, 2002
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6PDW
| Msp1-substrate complex in closed conformation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | 著者 | Wang, L, Myasnikov, A, Pan, X, Walter, P. | 登録日 | 2019-06-19 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife, 9, 2020
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2GPV
| Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide | 分子名称: | 4-HYDROXYTAMOXIFEN, Estrogen-related receptor gamma, Nuclear receptor corepressor 2 | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2GPP
| Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716 | 分子名称: | 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE, Estrogen-related receptor gamma, Nuclear receptor-interacting protein 1 | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2GPO
| Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140 | 分子名称: | Estrogen-related receptor gamma, Nuclear receptor-interacting protein 1 | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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2GPU
| Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen | 分子名称: | 4-HYDROXYTAMOXIFEN, Estrogen-related receptor gamma | 著者 | Wang, L, Zuercher, W.J, Consler, T.G, Lambert, M.H, Miller, A.B, Osband-Miller, L.A, McKee, D.D, Willson, T.M, Nolte, R.T. | 登録日 | 2006-04-18 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem., 281, 2006
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6EGA
| IRAK4 in complex with a type II inhibitor | 分子名称: | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Wang, L, Wu, H. | 登録日 | 2018-08-19 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.512 Å) | 主引用文献 | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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6EG9
| IRAK4 in complex with Ponatinib | 分子名称: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Wang, L, Wu, H. | 登録日 | 2018-08-19 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.414 Å) | 主引用文献 | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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4YPR
| Crystal Structure of D144N MutY bound to its anti-substrate | 分子名称: | A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ... | 著者 | Wang, L, Lee, S, Verdine, G.L. | 登録日 | 2015-03-13 | 公開日 | 2015-05-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase. J.Biol.Chem., 290, 2015
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7U4T
| Human V-ATPase in state 2 with SidK and mEAK-7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, MTOR-associated protein MEAK7, ... | 著者 | Wang, L, Fu, T.M. | 登録日 | 2022-03-01 | 公開日 | 2022-08-24 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining. Proc.Natl.Acad.Sci.USA, 119, 2022
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6LNI
| Cryo-EM structure of amyloid fibril formed by full-length human prion protein | 分子名称: | Major prion protein | 著者 | Wang, L.Q, Zhao, K, Yuan, H.Y, Wang, Q, Guan, Z.Y, Tao, J, Li, X.N, Hao, M.M, Chen, J, Zhang, D.L, Zhu, H.L, Yin, P, Liu, C, Liang, Y. | 登録日 | 2019-12-30 | 公開日 | 2020-06-10 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.702 Å) | 主引用文献 | Cryo-EM structure of an amyloid fibril formed by full-length human prion protein. Nat.Struct.Mol.Biol., 27, 2020
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7RLO
| Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs | 分子名称: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | 著者 | Wang, L, Schoof, M, Cogan, J, Lawrence, R, Boone, M, Wuerth, J, Frost, M, Walter, P. | 登録日 | 2021-07-26 | 公開日 | 2021-12-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12, 2021
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8E6U
| Human TRPM2 ion channel in 1 mM F-dADPR | 分子名称: | Transient receptor potential cation channel subfamily M member 2, [(2R,3S,5R)-5-(6-amino-8-phenyl-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | 登録日 | 2022-08-23 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6Q
| Human TRPM2 ion channel in 1 mM ADPR | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2 | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | 登録日 | 2022-08-23 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6R
| Human TRPM2 ion channel in 1 mM dADPR | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | 登録日 | 2022-08-23 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6T
| Human TRPM2 ion channel in 1 mM BR-ADPR | 分子名称: | (3R,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4,5-trihydroxypentyl [(2S,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name), Transient receptor potential cation channel subfamily M member 2 | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | 登録日 | 2022-08-23 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6S
| Human TRPM2 ion channel in 1 mM dADPR and Ca2+ | 分子名称: | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, ... | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | 登録日 | 2022-08-23 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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7UPT
| Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (open conformation) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P. | 登録日 | 2022-04-16 | 公開日 | 2022-06-15 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. Elife, 11, 2022
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7UPR
| Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (closed conformation) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Outer mitochondrial transmembrane helix translocase, ... | 著者 | Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P. | 登録日 | 2022-04-16 | 公開日 | 2022-06-15 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. Elife, 11, 2022
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6VP0
| Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Diacylglycerol O-acyltransferase 1, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Wang, L, Qian, H, Han, Y, Nian, Y, Ren, Z, Zhang, H, Hu, L, Prasad, B.V.V, Yan, N, Zhou, M. | 登録日 | 2020-02-01 | 公開日 | 2020-05-13 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature, 581, 2020
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6FXD
| Crystal structure of MupZ from Pseudomonas fluorescens | 分子名称: | MupZ | 著者 | Wang, L, Parnell, A, Williams, C, Bakar, N.A, van der Kamp, M.W, Simpson, T.J, Race, P.R, Crump, M.P, Willis, C.L. | 登録日 | 2018-03-08 | 公開日 | 2019-03-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis Nat Catal, 2018
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8ERP
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8ERO
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7CWS
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7TYJ
| Cryo-EM Structure of insulin receptor-related receptor (IRR) in apo-state captured at pH 7. The 3D refinement was focused on one of two halves with C1 symmetry applied | 分子名称: | Insulin receptor-related protein | 著者 | Wang, L.W, Hall, C, Li, J, Choi, E, Bai, X.C. | 登録日 | 2022-02-13 | 公開日 | 2023-02-15 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Nat.Struct.Mol.Biol., 30, 2023
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