8E6R

Human TRPM2 ion channel in 1 mM dADPR

Summary for 8E6R

• Entry DOI: 10.2210/pdb8e6r/pdb
• Related: 6MIZ
• EMDB information: 27923
• Descriptor: Transient receptor potential cation channel subfamily M member 2, ADENOSINE-5-DIPHOSPHORIBOSE, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE (3 entities in total)
• Functional Keywords: trpm2, trp, adpr, adp-ribose, nudt9h, nudt9, calcium, ion channel, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 690139.28

Authors

Wang, L.,Fu, T.M.,Xia, S.,Wu, H. (deposition date: 2022-08-23, release date: 2024-08-14, Last modification date: 2025-05-28)

• Primary citation: Wang, L.,Fu, T.-M.; A unified mechanism for human TRPM2 activation, desensitization and inhibition; To Be Published,

Experimental method

ELECTRON MICROSCOPY (5.6 Å)