6EGA

IRAK4 in complex with a type II inhibitor

Summary for 6EGA

DescriptorInterleukin-1 receptor-associated kinase 4, 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, SULFATE ION, ... (5 entities in total)
Functional Keywordsinhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight71349.88
Authors
Wang, L.,Wu, H. (deposition date: 2018-08-19, release date: 2019-02-20, Last modification date: 2019-12-18)
Primary citation
Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H.
Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294:4511-4519, 2019
PubMed: 30679311 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.005428
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.512 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2644 0.4% 2.6% 8.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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168889
PDB entries from 2020-09-16