6EGA
IRAK4 in complex with a type II inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-1 receptor-associated kinase 4 | polymer | 312 | 34821.5 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | C, I (A, B) | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | non-polymer | 580.6 | 2 | Chemie (J8A) | |||
| 3 | D, J (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, G, H, K... (A, B) | COBALT (II) ION | non-polymer | 58.9 | 6 | Chemie (CO) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, B: 154 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 149 | - | expression tag |
| Ala 150 | - | expression tag |
| Met 151 | - | expression tag |
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69642.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1707.0 | |
| All* | Total formula weight | 71349.9 |
