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PDB: 68 件
4PPT
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BU of 4ppt by Molmil
Engineered Dual Specific VHH Antibody in Complex with a Nickel (II) Ion
分子名称: Engineered single domain VHH antibody, NICKEL (II) ION, SULFATE ION
著者Fanning, S.W, Walter, R, Horn, J.R.
登録日2014-02-27
公開日2014-09-03
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.
Protein Eng.Des.Sel., 27, 2014
2ZNX
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BU of 2znx by Molmil
5-Fluorotryptophan Incorporated ScFv10 Complexed to Hen Egg Lysozyme
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Lysozyme C, ScFv
著者DeSantis, M.E, Acchione, M, Li, M, Walter, R.L, Wlodawer, A, Smith-Gill, S.
登録日2008-05-02
公開日2009-01-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics
Biochemistry, 51, 2012
2HFP
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BU of 2hfp by Molmil
Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands
分子名称: 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE, Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment
著者Pokross, M.E, Evdokimov, A.G, Walter, R.L, Mekel, M.J, Hopkins, C.R.
登録日2006-06-25
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
Bioorg.Med.Chem.Lett., 16, 2006
2I4H
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BU of 2i4h by Molmil
Structural studies of protein tyrosine phosphatase beta catalytic domain co-crystallized with a sulfamic acid inhibitor
分子名称: CHLORIDE ION, MAGNESIUM ION, N-(TERT-BUTOXYCARBONYL)-L-TYROSYL-N-METHYL-4-(SULFOAMINO)-L-PHENYLALANINAMIDE, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-08-21
公開日2006-08-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2HBU
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BU of 2hbu by Molmil
Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor
分子名称: Egl nine homolog 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
著者Evdokimov, A.G, Walter, R.L, Mekel, M, Pokross, M.E, Kawamoto, R, Boyer, A.
登録日2006-06-14
公開日2006-06-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of HIF prolyl hydroxylase in complex with a biologically active inhibitor
To be Published
2HC1
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BU of 2hc1 by Molmil
Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta.
分子名称: ACETATE ION, CHLORIDE ION, Receptor-type tyrosine-protein phosphatase beta
著者Evdokimov, A.G, Pokross, M, Walter, R, Mekel, M.
登録日2006-06-14
公開日2006-06-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
2HC2
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BU of 2hc2 by Molmil
Engineered protein tyrosine phosphatase beta catalytic domain
分子名称: MAGNESIUM ION, Receptor-type tyrosine-protein phosphatase beta, SODIUM ION
著者Evdokimov, A.G, Pokross, M, Walter, R, Mekel, M.
登録日2006-06-15
公開日2006-06-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
Acta Crystallogr.,Sect.D, 62, 2006
4NKF
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BU of 4nkf by Molmil
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Farnesyl pyrophosphate synthase, ...
著者Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E.
登録日2013-11-12
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4NG6
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BU of 4ng6 by Molmil
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
分子名称: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ...
著者Tsoumpra, M.K, Muniz, J.R.C, Barnett, B.L, Pilka, E, Kwaasi, A.A, Kavanagh, K.L, Evdokimov, A, Walter, R.L, Ebetino, F.H, Oppermann, U, Russell, R.G.G, Dunford, J.E.
登録日2013-11-01
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
TO BE PUBLISHED
4XI3
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BU of 4xi3 by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene
分子名称: Bazedoxifene, Estrogen receptor
著者Fanning, S.W, Mayne, C.G, Toy, W, Carlson, K, Greene, B, Nowak, J, Walter, R, Panchamukhi, S, Tajhorshid, E, Nettles, K.W, Chandarlapaty, S, Katzenellenbogen, J, Greene, G.L.
登録日2015-01-06
公開日2016-01-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Elife, 7, 2018
4NKE
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BU of 4nke by Molmil
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
分子名称: 1,2-ETHANEDIOL, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
著者Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E.
登録日2013-11-12
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
2GG2
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BU of 2gg2 by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: 5-IMINO-4-(3-TRIFLUOROMETHYL-PHENYLAZO)-5H-PYRAZOL-3-YLAMINE, COBALT (II) ION, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
2GG0
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BU of 2gg0 by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: COBALT (II) ION, METHYL N-{(2S,3R)-3-AMINO-2-HYDROXY-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOYL}ALANYLGLYCINATE, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
2GGB
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BU of 2ggb by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: COBALT (II) ION, METHYL N-[(2S,3R)-3-AMINO-2-HYDROXYHEPTANOYL]-L-SERYL-L-LEUCINATE, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
2GG8
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BU of 2gg8 by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: COBALT (II) ION, METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-METHYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
4NUA
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BU of 4nua by Molmil
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
分子名称: 1,2-ETHANEDIOL, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, ...
著者Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E.
登録日2013-12-03
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
2GG7
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BU of 2gg7 by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: 3-(5-AMINO-3-IMINO-3H-PYRAZOL-4-YLAZO)-BENZOIC ACID, COBALT (II) ION, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
2GG3
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Novel bacterial methionine aminopeptidase inhibitors
分子名称: 4-(4-FLUORO-PHENYLAZO)-5-IMINO-5H-PYRAZOL-3-YLAMINE, COBALT (II) ION, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
2GGC
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BU of 2ggc by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: COBALT (II) ION, METHIONINE, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
2GG5
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BU of 2gg5 by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: 5-IMINO-4-(2-TRIFLUOROMETHYL-PHENYLAZO)-5H-PYRAZOL-3-YLAMINE, COBALT (II) ION, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
2GG9
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BU of 2gg9 by Molmil
Novel bacterial methionine aminopeptidase inhibitors
分子名称: COBALT (II) ION, METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-ISOPROPYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE, Methionine aminopeptidase, ...
著者Evdokimov, A.G, Pokross, M.E, Walter, R.L, Mekel, M.
登録日2006-03-23
公開日2006-06-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
4N9U
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BU of 4n9u by Molmil
The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
分子名称: 1,2-ETHANEDIOL, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, ...
著者Tsoumpra, M.K, Muniz, J.R.C, Barnett, B.L, Pilka, E, Kwaasi, A.A, Kavanagh, K.L, Evdokimov, A, Walter, R.L, Ebetino, F.H, Oppermann, U, Russell, R.G.G, Dunford, J.E.
登録日2013-10-21
公開日2014-10-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
TO BE PUBLISHED
4Q23
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BU of 4q23 by Molmil
The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
分子名称: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ...
著者Tsoumpra, M.K, Muniz, J.R.C, Barnett, B.L, Kwaasi, A.A, Pilka, E.S, Kavanagh, K.L, Evdokimov, A, Walter, R.L, Ebetino, F.H, von Delft, F, Oppermann, U, Russell, R.G.G, Dunford, J.E.
登録日2014-04-05
公開日2015-03-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
To be Published
4OGU
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BU of 4ogu by Molmil
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ...
著者Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E.
登録日2014-01-16
公開日2015-01-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
2HBT
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Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor
分子名称: Egl nine homolog 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
著者Evdokimov, A.G, Walter, R.L, Mekel, M, Pokross, M.E, Kawamoto, R, Boyer, A.
登録日2006-06-14
公開日2006-06-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of HIF prolyl hydroxylase in complex with a biologically active inhibitor
To be Published

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