4N9U

The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates

Summary for 4N9U

• Entry DOI: 10.2210/pdb4n9u/pdb
• Related: 1YQ7 4KFA 4KPD 4KPJ 4KQ5 4KQS 4KQU 4NG6 4NKE 4NKF 4NUA
• Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ... (5 entities in total)
• Functional Keywords: alpha-helical prenyltransferase fold, isoprene biosynthesis, lipid synthesis, steroid biosynthesis, dimethylallyl pyrophosphate, isopentenyl pyrophosphate, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43583.04

Authors

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E. (deposition date: 2013-10-21, release date: 2014-10-22, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E.; The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.11 Å)