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PDB: 578 results

3KNV
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BU of 3knv by Molmil
Crystal structure of the RING and first zinc finger domains of TRAF2
Descriptor: TNF receptor-associated factor 2, ZINC ION
Authors:Yin, Q, Wu, H.
Deposit date:2009-11-12
Release date:2009-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
Biochemistry, 48, 2009
5IWZ
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BU of 5iwz by Molmil
Synaptonemal complex protein
Descriptor: Synaptonemal complex protein 2
Authors:Feng, J, Fu, S, Cao, X, Wu, H, Lu, J, Zeng, M, Liu, L, Yang, X, Shen, Y.
Deposit date:2016-03-23
Release date:2017-03-29
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Structure of synaptonemal complexes protein at 2.6 angstroms resolution
To Be Published
4N4W
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BU of 4n4w by Molmil
Structure of the human smoothened receptor in complex with SANT-1.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine, Cytochrome b(562),Smoothened homolog, ...
Authors:Wang, C, Wu, H, Han, G.W, Cherezov, V, Stevens, R.C, GPCR Network (GPCR)
Deposit date:2013-10-08
Release date:2014-01-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5, 2014
5XF8
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BU of 5xf8 by Molmil
Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state
Descriptor: Cell division cycle protein CDT1, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ...
Authors:Zhai, Y, Cheng, E, Wu, H, Li, N, Yung, P.Y, Gao, N, Tye, B.K.
Deposit date:2017-04-09
Release date:2017-05-03
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
4N0U
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BU of 4n0u by Molmil
Ternary complex between Neonatal Fc receptor, serum albumin and Fc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Ig gamma-1 chain C region, ...
Authors:Oganesyan, V, Wu, H, Dall'Acqua, W.F.
Deposit date:2013-10-02
Release date:2014-02-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.
J.Biol.Chem., 289, 2014
9BJU
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BU of 9bju by Molmil
Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
Descriptor: 1,2-ETHANEDIOL, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ACETATE ION, ...
Authors:Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A.
Deposit date:2024-04-25
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability
To Be Published
9BOL
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BU of 9bol by Molmil
Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
Descriptor: (4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A.
Deposit date:2024-05-03
Release date:2024-05-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability
To Be Published
6L62
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BU of 6l62 by Molmil
Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope
Descriptor: Capsid protein, Heavy chain of Fab fragment, Light chain of Fab fragment
Authors:Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C.
Deposit date:2019-10-25
Release date:2020-02-12
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
7PMO
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BU of 7pmo by Molmil
Ruminococcus gnavus ATC29149 endo-beta-1,4-galactosidase (RgGH98)
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Owen, C.D, Wu, H, Crost, E.H, van Bakel, W, Gascuena, A.M, Latousakis, D, Hicks, T, Walpole, S, Urbanowicz, P.A, Ndeh, D, Monaco, S, Salom, L.S, Griffiths, R, Colvile, A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N.
Deposit date:2021-09-02
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract.
Plos Biol., 19, 2021
7Q20
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BU of 7q20 by Molmil
Ruminococcus gnavus ATC29149 endo-beta-1,4-galactosidase (RgGH98) in complex with blood group A trisaccharide
Descriptor: CALCIUM ION, MAGNESIUM ION, Ruminococcus gnavus endogalactosidase GH98, ...
Authors:Owen, C.D, Wu, H, Crost, E.H, van Bakel, W, Gascuena, A.M, Latousakis, D, Hicks, T, Walpole, S, Urbanowicz, P.A, Ndeh, D, Monaco, S, Salom, L.S, Griffiths, R, Colvile, A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N.
Deposit date:2021-10-22
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract.
Plos Biol., 19, 2021
7Q1W
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BU of 7q1w by Molmil
Ruminococcus gnavus ATC29149 endo-beta-1,4-galactosidase (RgGH98) E411A in complex with blood group A (BgA II) tetrasaccharide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ...
Authors:Owen, C.D, Wu, H, Crost, E.H, van Bakel, W, Gascuena, A.M, Latousakis, D, Hicks, T, Walpole, S, Urbanowicz, P.A, Ndeh, D, Monaco, S, Salom, L.S, Griffiths, R, Colvile, A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N.
Deposit date:2021-10-21
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract.
Plos Biol., 19, 2021
6KW4
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BU of 6kw4 by Molmil
The ClassB RSC-Nucleosome Complex
Descriptor: Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ...
Authors:Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C.
Deposit date:2019-09-06
Release date:2019-11-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (7.55 Å)
Cite:Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
6XKJ
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BU of 6xkj by Molmil
Cryo-EM structure of CARD8-CARD filament
Descriptor: Caspase recruitment domain-containing protein 8
Authors:Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H.
Deposit date:2020-06-26
Release date:2020-11-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Nat Commun, 12, 2021
6X6A
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BU of 6x6a by Molmil
Cryo-EM structure of NLRP1-DPP9 complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6KW5
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BU of 6kw5 by Molmil
The ClassC RSC-Nucleosome Complex
Descriptor: Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ...
Authors:Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C.
Deposit date:2019-09-06
Release date:2020-09-09
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (10.13 Å)
Cite:Structure of the RSC complex bound to the nucleosome
To Be Published
6EG9
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BU of 6eg9 by Molmil
IRAK4 in complex with Ponatinib
Descriptor: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ...
Authors:Wang, L, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.414 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
6X6C
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BU of 6x6c by Molmil
Cryo-EM structure of NLRP1-DPP9-VbP complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ...
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
7TDZ
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BU of 7tdz by Molmil
Cryo-EM model of protomer of the cytoplasmic ring of the nuclear pore complex from Xenopus laevis
Descriptor: Nuclear pore complex protein, Nuclear pore complex protein Nup85, Nuclear pore complex protein Nup96, ...
Authors:Fontana, P, Wu, H.
Deposit date:2022-01-03
Release date:2022-06-22
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold.
Science, 376, 2022
1FLK
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BU of 1flk by Molmil
MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3
Descriptor: TNF RECEPTOR ASSOCIATED FACTOR 3
Authors:Ni, C.-Z, Welsh, K, Leo, E, Chiou, C.-K, Wu, H, Reed, J.C, Ely, K.R.
Deposit date:2000-08-14
Release date:2000-10-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for CD40 signaling mediated by TRAF3.
Proc.Natl.Acad.Sci.USA, 97, 2000
3VK0
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BU of 3vk0 by Molmil
Crystal Structure of hypothetical transcription factor NHTF from Neisseria
Descriptor: Transcriptional regulator
Authors:Wang, H.-C, Ko, T.-P, Wu, M.-L, Wu, H.-J, Ku, S.-C, Wang, A.H.-J.
Deposit date:2011-11-01
Release date:2012-03-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor
Nucleic Acids Res., 2012
6EGF
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BU of 6egf by Molmil
Crystal structure of the inactive unphosphorylated IRAK4 kinase domain bound to AMP-PNP
Descriptor: Interleukin-1 receptor-associated kinase 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ferrao, R, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
6EGD
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BU of 6egd by Molmil
Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor
Descriptor: Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide
Authors:Ferrao, R, Wu, H.
Deposit date:2018-08-19
Release date:2019-02-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
4U6V
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BU of 4u6v by Molmil
Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody
Descriptor: Alpha-hemolysin, Fab, antigen binding fragment, ...
Authors:Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F.
Deposit date:2014-07-29
Release date:2014-09-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
J.Biol.Chem., 289, 2014
4U97
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BU of 4u97 by Molmil
Crystal Structure of Asymmetric IRAK4 Dimer
Descriptor: Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
Authors:Ferrao, R, Wu, H.
Deposit date:2014-08-05
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
2E0H
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BU of 2e0h by Molmil
Solution Structure of BmKalphaIT01, an alpha-insect toxin from the Venom of the Chinese Scorpion Buthus martensi Karsch
Descriptor: Alpha-neurotoxin TX12
Authors:Tong, X.T, Chen, X, Wu, H.M.
Deposit date:2006-10-08
Release date:2007-10-16
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution Structure of BmKalphaIT01, an alpha-Insect Toxin from the Venom of the Chinese Scorpion Buthus martensii Karsch
Biochemistry, 46, 2007

221051

数据于2024-06-12公开中

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