8E4Y
Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with 2-oxohexadecyl-CoA
Summary for 8E4Y
Entry DOI | 10.2210/pdb8e4y/pdb |
Related | 8E50 |
EMDB information | 27898 |
Descriptor | Glycerol-3-phosphate acyltransferase 1, mitochondrial, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(2-oxohexadecyl)sulfanyl]ethyl}amino)propyl]amino}butyl dihydrogen diphosphate (non-preferred name), (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate (3 entities in total) |
Functional Keywords | acyltransferase, lpa, monotopic, mitochondrial, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 88335.89 |
Authors | Johnson, Z.L.,Wasilko, D.J.,Ammirati, M.,Chang, J.S.,Han, S.,Wu, H. (deposition date: 2022-08-19, release date: 2022-12-21, Last modification date: 2024-06-12) |
Primary citation | Johnson, Z.L.,Ammirati, M.,Wasilko, D.J.,Chang, J.S.,Noell, S.,Foley, T.L.,Yoon, H.,Smith, K.,Asano, S.,Hales, K.,Wan, M.,Yang, Q.,Piotrowski, M.A.,Farley, K.A.,Gilbert, T.,Aschenbrenner, L.M.,Fennell, K.F.,Dutra, J.K.,Xu, M.,Guo, C.,Varghese, A.E.,Bellenger, J.,Quinn, A.,Am Ende, C.W.,West, G.M.,Griffor, M.C.,Bennett, D.,Calabrese, M.,Steppan, C.M.,Han, S.,Wu, H. Structural basis of the acyl-transfer mechanism of human GPAT1. Nat.Struct.Mol.Biol., 30:22-30, 2023 Cited by PubMed: 36522428DOI: 10.1038/s41594-022-00884-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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