1DIA

HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY249543

Summary for 1DIA

Related1A4I 1DIB 1DIG
DescriptorMETHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [[[2-AMINO-5,6,7,8-TETRAHYDRO-4-HYDROXY-PYRIDO[2,3-D]PYRIMIDIN-6-YL]-ETHYL]-PHENYL]-CARBONYL-GLUTAMIC ACID, ... (4 entities in total)
Functional Keywordstetrahydrofolate, dehydrogenase, cyclohydrolase, nadp, inhibitor, rossmann fold, oxidoreductase, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P11586
Total number of polymer chains2
Total molecular weight68607.1
Authors
Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. (deposition date: 1999-11-29, release date: 2000-07-05, Last modification date: 2018-01-31)
Primary citation
Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M.
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
Biochemistry, 39:6325-6335, 2000
PubMed: 10828945 (PDB entries with the same primary citation)
DOI: 10.1021/bi992734y
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.265601.0%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report