1DIG
HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY374571
Summary for 1DIG
Entry DOI | 10.2210/pdb1dig/pdb |
Related | 1A4I 1DIA 1DIB |
Descriptor | METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [[N'-(2,5-DIAMINO-6-HYDROXY-PYRIMIDIN-4-YL)-UREAYL]-PHEN-4-YL]-CARBONYL-GLUTAMIC ACID, ... (5 entities in total) |
Functional Keywords | tetrahydrofolate, dehydrogenase, cyclohydrolase, nadp, inhibitor, rossmann fold, oxidoreductase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P11586 |
Total number of polymer chains | 2 |
Total formula weight | 68656.06 |
Authors | Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. (deposition date: 1999-11-29, release date: 2000-07-05, Last modification date: 2024-02-07) |
Primary citation | Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry, 39:6325-6335, 2000 Cited by PubMed: 10828945DOI: 10.1021/bi992734y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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