1DIG

HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY374571

Summary for 1DIG

• Entry DOI: 10.2210/pdb1dig/pdb
• Related: 1A4I 1DIA 1DIB
• Descriptor: METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [[N'-(2,5-DIAMINO-6-HYDROXY-PYRIMIDIN-4-YL)-UREAYL]-PHEN-4-YL]-CARBONYL-GLUTAMIC ACID, ... (5 entities in total)
• Functional Keywords: tetrahydrofolate, dehydrogenase, cyclohydrolase, nadp, inhibitor, rossmann fold, oxidoreductase, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P11586
• Total number of polymer chains: 2
• Total formula weight: 68656.06

Authors

Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. (deposition date: 1999-11-29, release date: 2000-07-05, Last modification date: 2024-02-07)

• Primary citation: Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M.; Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.; Biochemistry, 39:6325-6335, 2000; PubMed: 10828945; DOI: 10.1021/bi992734y

Experimental method

X-RAY DIFFRACTION (2.2 Å)