1DIB
HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY345899
Summary for 1DIB
Entry DOI | 10.2210/pdb1dib/pdb |
Related | 1A4I 1DIA 1DIG |
Descriptor | METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID, ... (4 entities in total) |
Functional Keywords | dehydrogenase, cyclohydrolase, nadp, inhibitor, rossmann fold, oxidoreductase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P11586 |
Total number of polymer chains | 2 |
Total formula weight | 68635.07 |
Authors | Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. (deposition date: 1999-11-29, release date: 2000-07-05, Last modification date: 2024-02-07) |
Primary citation | Schmidt, A.,Wu, H.,MacKenzie, R.E.,Chen, V.J.,Bewly, J.R.,Ray, J.E.,Toth, J.E.,Cygler, M. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry, 39:6325-6335, 2000 Cited by PubMed: 10828945DOI: 10.1021/bi992734y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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