Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE NAP A 2001 |
Chain | Residue |
A | THR148 |
A | MET221 |
A | CYS236 |
A | GLY237 |
A | ILE238 |
A | GLY276 |
A | THR279 |
A | L243001 |
A | HOH4093 |
A | ARG173 |
A | SER174 |
A | HIS196 |
A | SER197 |
A | LEU202 |
A | THR216 |
A | GLY217 |
A | GLN218 |
site_id | AC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAP B 2002 |
Chain | Residue |
B | THR1148 |
B | ARG1173 |
B | SER1174 |
B | HIS1196 |
B | SER1197 |
B | THR1216 |
B | GLY1217 |
B | GLN1218 |
B | MET1221 |
B | CYS1236 |
B | ILE1238 |
B | GLY1276 |
B | THR1279 |
B | HOH4018 |
B | HOH4019 |
B | HOH4108 |
B | HOH4109 |
B | HOH4110 |
B | HOH4111 |
B | HOH4185 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE L24 A 3001 |
Chain | Residue |
A | TYR52 |
A | VAL55 |
A | LYS56 |
A | GLN100 |
A | LEU101 |
A | PRO272 |
A | GLY273 |
A | PRO277 |
A | VAL280 |
A | NAP2001 |
A | HOH4132 |
Functional Information from PROSITE/UniProt
site_id | PS00766 |
Number of Residues | 26 |
Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EsEVMkyItsLNeDstvhgFLVQLPL |
Chain | Residue | Details |
A | GLU78-LEU103 | |
site_id | PS00767 |
Number of Residues | 9 |
Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
Chain | Residue | Details |
A | PRO272-VAL280 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | LYS56 | |
B | LYS1056 | |
Chain | Residue | Details |
A | TYR52 | |
A | VAL99 | |
A | PRO272 | |
B | TYR1052 | |
B | VAL1099 | |
B | PRO1272 | |
Chain | Residue | Details |
A | GLY172 | |
A | SER197 | |
B | GLY1172 | |
B | SER1197 | |
Chain | Residue | Details |
A | MET1 | |
B | MET1001 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a4i |
Chain | Residue | Details |
A | LYS56 | |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a4i |
Chain | Residue | Details |
B | LYS1056 | |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 389 |
Chain | Residue | Details |
A | LYS56 | activator |
A | GLN100 | activator |
A | ASP125 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 458 |
Chain | Residue | Details |
A | SER49 | activator |
A | LYS56 | proton shuttle (general acid/base) |
A | GLN100 | activator |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 389 |
Chain | Residue | Details |
B | LYS1056 | activator |
B | GLN1100 | activator |
B | ASP1125 | electrostatic stabiliser |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 458 |
Chain | Residue | Details |
B | SER1049 | activator |
B | LYS1056 | proton shuttle (general acid/base) |
B | GLN1100 | activator |