7LFH

Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)

Summary for 7LFH

• Entry DOI: 10.2210/pdb7lfh/pdb
• EMDB information: 23302 23303 23304 23305
• Descriptor: NACHT, LRR and PYD domains-containing protein 3 (1 entity in total)
• Functional Keywords: nlrp3, nek7, nucleotid-binding, atp-binding, inflammasome, immunity, innate immunity, nacht, lrr, pyd, immune system
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 12
• Total formula weight: 1425626.63

Authors

Andreeva, L.,Rawson, S.,Wu, H. (deposition date: 2021-01-17, release date: 2021-12-15, Last modification date: 2022-04-27)

• Primary citation: Andreeva, L.,David, L.,Rawson, S.,Shen, C.,Pasricha, T.,Pelegrin, P.,Wu, H.; NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.; Cell, 184:6299-, 2021; PubMed: 34861190; DOI: 10.1016/j.cell.2021.11.011

Experimental method

ELECTRON MICROSCOPY (4.2 Å)