7LFH

Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	NACHT, LRR and PYD domains-containing protein 3	polymer	1037	118802.2	12	UniProt (Q8R4B8) Pfam (PF02758) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) Pfam (PF13516) In PDB	Mus musculus (house mouse)	Cold autoinflammatory syndrome 1 protein homolog,Cryopyrin,Mast cell maturation-associated-inducible protein 1,PYRIN-containing APAF1-like protein 1

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 1 - 1033 (UniProt: Q8R4B8)

PDB	External Database	Details
Gly -3	-	expression tag
Arg -2	-	expression tag
Ser -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	1425626.6
All*	Total formula weight	1425626.6

*Water molecules are not included.