8E50

Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with CoA and palmitoyl-LPA

Summary for 8E50

• Entry DOI: 10.2210/pdb8e50/pdb
• Related: 8E4Y
• EMDB information: 27898 27899
• Descriptor: Glycerol-3-phosphate acyltransferase 1, mitochondrial, COENZYME A, (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate (3 entities in total)
• Functional Keywords: acyltransferase, lpa, monotopic, mitochondrial, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 88097.49

Authors

Wasilko, D.J.,Johnson, Z.L.,Ammirati, M.,Chang, J.S.,Han, S.,Wu, H. (deposition date: 2022-08-19, release date: 2022-12-21, Last modification date: 2023-02-01)

• Primary citation: Johnson, Z.L.,Ammirati, M.,Wasilko, D.J.,Chang, J.S.,Noell, S.,Foley, T.L.,Yoon, H.,Smith, K.,Asano, S.,Hales, K.,Wan, M.,Yang, Q.,Piotrowski, M.A.,Farley, K.A.,Gilbert, T.,Aschenbrenner, L.M.,Fennell, K.F.,Dutra, J.K.,Xu, M.,Guo, C.,Varghese, A.E.,Bellenger, J.,Quinn, A.,Am Ende, C.W.,West, G.M.,Griffor, M.C.,Bennett, D.,Calabrese, M.,Steppan, C.M.,Han, S.,Wu, H.; Structural basis of the acyl-transfer mechanism of human GPAT1.; Nat.Struct.Mol.Biol., 30:22-30, 2023; PubMed: 36522428; DOI: 10.1038/s41594-022-00884-7

Experimental method

ELECTRON MICROSCOPY (3.67 Å)