8E50
Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with CoA and palmitoyl-LPA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004366 | molecular_function | glycerol-3-phosphate O-acyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006650 | biological_process | glycerophospholipid metabolic process |
| A | 0006651 | biological_process | diacylglycerol biosynthetic process |
| A | 0006654 | biological_process | phosphatidic acid biosynthetic process |
| A | 0006655 | biological_process | phosphatidylglycerol biosynthetic process |
| A | 0008374 | molecular_function | O-acyltransferase activity |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0016024 | biological_process | CDP-diacylglycerol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0019432 | biological_process | triglyceride biosynthetic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"36522428","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E50","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Motif: {"description":"HXXXXD motif","evidences":[{"source":"PubMed","id":"36522428","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36522428","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E4Y","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P97564","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q61586","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
