8E50

Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with CoA and palmitoyl-LPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001817	biological_process	regulation of cytokine production
A	0004366	molecular_function	glycerol-3-phosphate O-acyltransferase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0006650	biological_process	glycerophospholipid metabolic process
A	0006651	biological_process	diacylglycerol biosynthetic process
A	0006654	biological_process	phosphatidic acid biosynthetic process
A	0006655	biological_process	phosphatidylglycerol biosynthetic process
A	0006924	biological_process	activation-induced cell death of T cells
A	0008374	molecular_function	O-acyltransferase activity
A	0008654	biological_process	phospholipid biosynthetic process
A	0009749	biological_process	response to glucose
A	0016020	cellular_component	membrane
A	0016024	biological_process	CDP-diacylglycerol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0019432	biological_process	triglyceride biosynthetic process
A	0040018	biological_process	positive regulation of multicellular organism growth
A	0042104	biological_process	positive regulation of activated T cell proliferation
A	0050798	biological_process	activated T cell proliferation
A	0051607	biological_process	defense response to virus
A	0055089	biological_process	fatty acid homeostasis
A	0055091	biological_process	phospholipid homeostasis
A	0070236	biological_process	negative regulation of activation-induced cell death of T cells

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"36522428","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E50","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Motif: {"description":"HXXXXD motif","evidences":[{"source":"PubMed","id":"36522428","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36522428","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E4Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P97564","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q61586","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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