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PDB: 89 件
1S14
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Crystal structure of Escherichia coli Topoisomerase IV ParE 24kDa subunit
分子名称: NOVOBIOCIN, Topoisomerase IV subunit B
著者Wei, Y, Gross, C.H.
登録日2004-01-05
公開日2004-05-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
1S16
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Crystal Structure of E. coli Topoisomerase IV ParE 43kDa subunit complexed with ADPNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ...
著者Wei, Y, Gross, C.H.
登録日2004-01-05
公開日2004-05-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
2PP4
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BU of 2pp4 by Molmil
Solution Structure of ETO-TAFH refined in explicit solvent
分子名称: Protein ETO
著者Wei, Y, Liu, S, Lausen, J, Woodrell, C, Cho, S, Biris, N, Kobayashi, N, Yokoyama, S, Werner, M.H.
登録日2007-04-27
公開日2007-06-19
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription
Nat.Struct.Mol.Biol., 14, 2007
3B92
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Novel thio-based TACE inhibitors Part 2: Rational design, synthesis and SAR of thiol-contaning aryl sufones
分子名称: 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol, ADAM 17, ZINC ION
著者Wei, Y.
登録日2007-11-02
公開日2007-12-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
Bioorg.Med.Chem.Lett., 18, 2008
2QV1
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Crystal structure of HCV NS3-4A V36M mutant
分子名称: NS3, ZINC ION, peptide
著者Wei, Y.
登録日2007-08-07
公開日2008-08-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Phenotypic and Structural Analyses of HCV NS3 Protease Val36 Variants
To be Published
3G7E
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BU of 3g7e by Molmil
Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor
分子名称: DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate
著者Wei, Y, Charifson, P.
登録日2009-02-09
公開日2010-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3G7B
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Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor
分子名称: DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate
著者Wei, Y, Charisfon, P.
登録日2009-02-09
公開日2010-02-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3FV5
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Crystal Structure of E. coli Topoisomerase IV co-complexed with inhibitor
分子名称: 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea, DNA topoisomerase 4 subunit B
著者Wei, Y, Charifson, P, LeTiran, A.
登録日2009-01-15
公開日2010-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity
To be Published
3G75
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Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor
分子名称: 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole, DNA gyrase subunit B
著者Wei, Y, Charifson, P.
登録日2009-02-09
公開日2010-02-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
1B62
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MUTL COMPLEXED WITH ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (MUTL)
著者Wei, Y.
登録日1999-01-11
公開日1999-04-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair.
Cell(Cambridge,Mass.), 97, 1999
7E7Y
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BU of 7e7y by Molmil
Crystal structure of the SARS-CoV-2 S RBD in complex with BD-623 Fab
分子名称: BD-623 Fab H, BD-623 Fab L, Spike protein S1
著者Wei, Y, Xiao, J.
登録日2021-02-28
公開日2021-06-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.
Cell Res., 31, 2021
2OIN
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BU of 2oin by Molmil
crystal structure of HCV NS3-4A R155K mutant
分子名称: NS4A peptide, Polyprotein, ZINC ION
著者Wei, Y.
登録日2007-01-11
公開日2007-06-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
J.Biol.Chem., 282, 2007
2OI0
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BU of 2oi0 by Molmil
Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide
分子名称: (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL, TNF- a Converting Enzyme (TACE), ZINC ION
著者Wei, Y, Rao, G.B, Bandarage, U.K.
登録日2007-01-10
公開日2007-11-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
Bioorg.Med.Chem.Lett., 17, 2007
2P59
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Crystal Structure of Hepatitis C Virus NS3.4A protease
分子名称: (2S,3AS,7AS)-1-[(2S)-2-{[(2S)-2-CYCLOHEXYL-2-({[(2R)-4-NITRO-2H-PYRROL-2-YL]CARBONYL}AMINO)ACETYL]AMINO}-3,3-DIMETHYLBUTANOYL]-N-{(1S)-1-[(1R)-2-(CYCLOPROPYLAMINO)-1-HYDROXY-2-OXOETHYL]BUTYL}OCTAHYDRO-1H-INDOLE-2-CARBOXAMIDE, NS3, peptide
著者Perni, R.B, Wei, Y.
登録日2007-03-14
公開日2008-02-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Bioorg.Med.Chem.Lett., 17, 2007
5MV1
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Crystal structure of the E protein of the Japanese encephalitis virulent virus
分子名称: E protein
著者Liu, X, Zhao, X, Na, R, Li, L, Warkentin, E, Witt, J, Lu, X, Wei, Y, Peng, G, Li, Y, Wang, J.
登録日2017-01-14
公開日2018-05-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism.
Protein Cell, 10, 2019
5MV2
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BU of 5mv2 by Molmil
Crystal structure of the E protein of the Japanese encephalitis live attenuated vaccine virus
分子名称: E protein
著者Liu, X, Zhao, X, Na, R, Li, L, Warkentin, E, Witt, J, Lu, X, Wei, Y, Peng, G, Li, Y, Wang, J.
登録日2017-01-14
公開日2018-05-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism.
Protein Cell, 10, 2019
6L62
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BU of 6l62 by Molmil
Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope
分子名称: Capsid protein, Heavy chain of Fab fragment, Light chain of Fab fragment
著者Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C.
登録日2019-10-25
公開日2020-02-12
最終更新日2020-04-29
実験手法ELECTRON MICROSCOPY (7.2 Å)
主引用文献Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
1WAB
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BU of 1wab by Molmil
PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
分子名称: ACETATE ION, PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
著者Ho, Y.S, Swenson, L, Derewenda, U, Serre, L, Wei, Y, Dauter, Z, Hattori, M, Aoki, J, Arai, H, Adachi, T, Inoue, K, Derewenda, Z.S.
登録日1996-10-30
公開日1997-11-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Nature, 385, 1997
8SE7
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BU of 8se7 by Molmil
HTRA-1 PDSA bound to CKP 1A8
分子名称: Cysteine knot peptide, Serine protease HTRA1
著者Ultsch, M.H, Kirchhofer, D, Wei, Y.
登録日2023-04-08
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献HTRA-1 PDSA bound to CKP 1A8
To Be Published
8SDM
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BU of 8sdm by Molmil
HTRA-1 PDSA bound to CKP 3B3
分子名称: Cysteine-containing peptide 3B3, Serine protease HTRA1
著者Ultsch, M.H, Kirchhofer, D, Wei, Y.
登録日2023-04-07
公開日2024-07-03
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献HTRA-1 PDSA bound to CKP 3B3
To Be Published
8SDP
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HTRA-1 PDSA bound to CKP 3A7
分子名称: Cysteine knot peptide 3A7, SULFATE ION, Serine protease HTRA1
著者Ultsch, M.H, Kirchhofer, D, Wei, Y.
登録日2023-04-07
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献HTRA-1 PDSA bound to CKP 3A7
To Be Published
6VTI
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BU of 6vti by Molmil
Solution NMR structure of the N-terminal domain of the Serine/threonine-protein phosphatase 1 regulatory subunit 10, PPP1R10
分子名称: Serine/threonine-protein phosphatase 1 regulatory subunit 10
著者Lemak, A, Wei, Y, Duan, S, Houliston, S, Penn, L.Z, Arrowsmith, C.H.
登録日2020-02-12
公開日2020-02-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Nucleic Acids Res., 50, 2022
1GGD
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BU of 1ggd by Molmil
CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-LEUCIL-PHENYLALANINE ALDEHYDE BOUND AT THE ACTIVE SITE
分子名称: 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE, GAMMA CHYMOTRYPSIN, SULFATE ION
著者Neidhart, D, Wei, Y, Cassidy, C, Lin, J, Cleland, W.W, Frey, P.A.
登録日2000-08-14
公開日2000-09-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin.
Biochemistry, 40, 2000
8HGH
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Structure of 2:2 PAPP-A.STC2 complex
分子名称: Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1, Stanniocalcin-2, ZINC ION
著者Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J.
登録日2022-11-14
公開日2023-01-11
実験手法ELECTRON MICROSCOPY (4.16 Å)
主引用文献Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022
8HGG
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Structure of 2:2 PAPP-A.ProMBP complex
分子名称: Bone marrow proteoglycan, Pappalysin-1, ZINC ION
著者Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J.
登録日2022-11-14
公開日2023-01-11
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022

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