2OIN

crystal structure of HCV NS3-4A R155K mutant

Summary for 2OIN

Entry DOI	10.2210/pdb2oin/pdb
Descriptor	Polyprotein, NS4A peptide, ZINC ION, ... (4 entities in total)
Functional Keywords	hcv, protease, ns3-4a, r155k mutant, hydrolase
Biological source	Hepatitis C virus More
Total number of polymer chains	4
Total formula weight	46696.39
Authors	Wei, Y. (deposition date: 2007-01-11, release date: 2007-06-05, Last modification date: 2024-04-03)
Primary citation	Zhou, Y.,Muh, U.,Hanzelka, B.L.,Bartels, D.J.,Wei, Y.,Rao, B.G.,Brennan, D.L.,Tigges, A.M.,Swenson, L.,Kwong, A.D.,Lin, C. Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha. J.Biol.Chem., 282:22619-22628, 2007 Cited by PubMed: 17556358 DOI: 10.1074/jbc.M610207200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation