2OI0

Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide

Summary for 2OI0

Entry DOI	10.2210/pdb2oi0/pdb
Descriptor	TNF- a Converting Enzyme (TACE), ZINC ION, (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL, ... (4 entities in total)
Functional Keywords	tnf-a coverting enzyme, aryl-sulfonamide, tace inhibitors, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P78536
Total number of polymer chains	1
Total formula weight	30413.49
Authors	Wei, Y.,Rao, G.B.,Bandarage, U.K. (deposition date: 2007-01-10, release date: 2007-11-27, Last modification date: 2023-08-30)
Primary citation	Govinda Rao, B.,Bandarage, U.K.,Wang, T.,Come, J.H.,Perola, E.,Wei, Y.,Tian, S.K.,Saunders, J.O. Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides Bioorg.Med.Chem.Lett., 17:2250-2253, 2007 Cited by PubMed: 17289381 DOI: 10.1016/j.bmcl.2007.01.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation