2OI0
Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TNF- a Converting Enzyme (TACE) | polymer | 266 | 30036.7 | 1 | UniProt (P78536) Pfam (PF13688) | Homo sapiens (human) | A disintegrin and metalloproteinase domain 17, TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, CD156b antigen |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL | non-polymer | 311.4 | 1 | Chemie (283) | |||
| 4 | D (A) | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A: 216 - 477 (UniProt: P78536)
| PDB | External Database | Details |
|---|---|---|
| Ala 266 | Ser 266 | engineered mutation |
| Gln 452 | Asn 452 | engineered mutation |
| Ile 478 | - | expression tag |
| Glu 479 | - | expression tag |
| Gly 480 | - | expression tag |
| Arg 481 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30036.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 376.8 | |
| All* | Total formula weight | 30413.5 |
