4CRD
 
 | | Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design | | 分子名称: | COAGULATION FACTOR XI, Methyl N-[4-[5-chloro-2-[[3-[5-chloro-2-(tetrazol-1-yl)phenyl]propanoylamino]methyl]-1H-imidazol-4-yl]phenyl]carbamate, SULFATE ION | | 著者 | Sandmark, J, Oster, L, Fjellstrom, O, Akkaya, S, Beisel, H.G, Eriksson, P.O, Erixon, K, Gustafsson, D, Jurva, U, Kang, D, Karis, D, Knecht, W, Nerme, V, Nilsson, I, Olsson, T, Redzic, A, Roth, R, Tigerstrom, A. | | 登録日 | 2014-02-26 | | 公開日 | 2015-02-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design.
Plos One, 10, 2015
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4CI0
 | | Electron cryo-microscopy of F420-reducing NiFe hydrogenase Frh | | 分子名称: | F420-REDUCING HYDROGENASE, SUBUNIT ALPHA, SUBUNIT BETA, ... | | 著者 | Allegretti, M, Mills, D.J, McMullan, G, Kuehlbrandt, W, Vonck, J. | | 登録日 | 2013-12-05 | | 公開日 | 2014-02-26 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Atomic Model of the F420-Reducing [Nife] Hydrogenase by Electron Cryo-Electron Microscopy Using a Direct Electron Detector.
Elife, 3, 2014
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8WUL
 | | Crystal structure of affinity enhanced TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | | 分子名称: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen, ... | | 著者 | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | | 登録日 | 2023-10-20 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen.
Commun Biol, 7, 2024
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5JN8
 | | Crystal Structure for the complex of human carbonic anhydrase IV and acetazolamide | | 分子名称: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ACETATE ION, Carbonic anhydrase 4, ... | | 著者 | Chen, Z, Waheed, A, Di Cera, E, Sly, W.S. | | 登録日 | 2016-04-29 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
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4CSD
 | | Structure of Monomeric Ralstonia solanacearum lectin | | 分子名称: | FUCOSE-BINDING LECTIN PROTEIN, GLYCEROL, methyl alpha-L-fucopyranoside | | 著者 | Arnaud, J, Trundle, K, Claudinon, J, Audfray, A, Varrot, A, Romer, W, Imberty, A. | | 登録日 | 2014-03-06 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Membrane Deformation by Neolectins with Engineered Glycolipid Binding Sites.
Angew.Chem.Int.Ed.Engl., 53, 2014
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8WOS
 | | Cryo-EM structure of human SIDT1 protein with C1 symmetry at low pH | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Liu, W, Tang, M, Wang, J, Zhang, X, Wu, S, Ru, H. | | 登録日 | 2023-10-07 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1.
Cell Discov, 10, 2024
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4HCS
 | | Structure of Novel subfamily CX chemokine solved by sulfur SAD | | 分子名称: | Uncharacterized protein | | 著者 | Rajasekaran, D, Fan, C, Meng, W, Pflugrath, J.W, Lolis, E.J. | | 登録日 | 2012-10-01 | | 公開日 | 2013-10-16 | | 最終更新日 | 2014-04-23 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Structural insight into the evolution of a new chemokine family from zebrafish.
Proteins, 82, 2014
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4CS2
 | | Catalytic domain of Pyrrolysyl-tRNA synthetase mutant Y306A, Y384F in its apo form | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PYRROLYSINE--TRNA LIGASE | | 著者 | Schmidt, M.J, Weber, A, Pott, M, Welte, W, Summerer, D. | | 登録日 | 2014-03-04 | | 公開日 | 2014-04-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells.
Chembiochem, 15, 2014
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4MGR
 | | The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT | | 分子名称: | ACETATE ION, HTH-type transcriptional regulatory protein GabR, IMIDAZOLE, ... | | 著者 | Wu, R, Edayathumangalam, R, Garcia, R, Wang, Y, Wang, W, Kreinbring, C.A, Bach, A, Liao, J, Stone, T, Terwilliger, T, Hoang, Q.Q, Belitsky, B.R, Petsko, G.A, Ringe, D, Liu, D. | | 登録日 | 2013-08-28 | | 公開日 | 2013-10-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3SK2
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4E2F
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8WTE
 | | Crystal structure of TCR in complex with HLA-A*11:01 bound to KRAS-G12V peptide (VVGAVGVGK) | | 分子名称: | Beta-2-microglobulin, KRAS-G12V nonamer peptide, MHC class I antigen (Fragment), ... | | 著者 | Zhang, M.Y, Luo, L.J, Xu, W, Guan, F.H, Wang, X.Y, Zhu, P, Zhang, J.H, Zhou, X.Y, Wang, F, Ye, S. | | 登録日 | 2023-10-18 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Identification and affinity enhancement of T-cell receptor targeting a KRAS G12V cancer neoantigen.
Commun Biol, 7, 2024
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4DX8
 | | ICAP1 in complex with KRIT1 N-terminus | | 分子名称: | BROMIDE ION, Integrin beta-1-binding protein 1, Krev interaction trapped protein 1 | | 著者 | Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-02-27 | | 公開日 | 2013-01-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
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4DXC
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3RY5
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8WY0
 | | T cell receptor delta 2 gamma 9 with F283A, F290A, and F291A | | 分子名称: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | | 著者 | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | 登録日 | 2023-10-30 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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4E21
 | | The crystal structure of 6-phosphogluconate dehydrogenase from Geobacter metallireducens | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 6-phosphogluconate dehydrogenase (Decarboxylating) | | 著者 | Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, Lafleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2012-03-07 | | 公開日 | 2012-03-21 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | The crystal structure of 6-phosphogluconate dehydrogenase from Geobacter metallireducens
To be Published
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4GTT
 | | Engineered RabGGTase in complex with BMS analogue 12 | | 分子名称: | 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate, CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, ... | | 著者 | Guo, Z, Stigter, E.A, Bon, R.S, Waldmann, H, Blankenfeldt, W, Goody, R.S. | | 登録日 | 2012-08-29 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Development of Selective, Potent RabGGTase Inhibitors
J.Med.Chem., 55, 2012
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4E1Y
 | | Alginate lyase A1-III H192A apo form | | 分子名称: | Alginate lyase | | 著者 | Mikami, B, Ban, M, Suzuki, S, Yoon, H.-J, Miyake, O, Yamasaki, M, Ogura, K, Maruyama, Y, Hashimoto, W, Murata, K. | | 登録日 | 2012-03-07 | | 公開日 | 2012-04-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Induced-fit motion of a lid loop involved in catalysis in alginate lyase A1-III
Acta Crystallogr.,Sect.D, 68, 2012
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8WYI
 | | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | | 分子名称: | Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | | 著者 | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | 登録日 | 2023-10-31 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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4LAO
 | | Crystal structure of Cordyceps militaris IDCase H195A mutant (Zn) | | 分子名称: | Cordyceps militaris IDCase, DI(HYDROXYETHYL)ETHER, ZINC ION | | 著者 | Xu, S, Li, W, Zhu, J, Ding, J. | | 登録日 | 2013-06-20 | | 公開日 | 2013-10-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
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4L6X
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4GX0
 | | Crystal structure of the GsuK L97D mutant | | 分子名称: | CALCIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | | 著者 | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | 登録日 | 2012-09-03 | | 公開日 | 2012-12-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
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8WXE
 | | Vgamma5Vdelta1 EH TCR-CD3 complex | | 分子名称: | CHOLESTEROL, Signal peptide,flag tag,T cell receptor delta variable 1,T cell receptor delta constant, Signal peptide,flag tag,T cell receptor gamma variable 5,T cell receptor gamma constant 1, ... | | 著者 | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | 登録日 | 2023-10-28 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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4HE6
 | | Crystal structure of the C-terminal domain of Geobacillus thermoleovorans putative U32 peptidase | | 分子名称: | ACETATE ION, Peptidase family U32, UNKNOWN ATOM OR ION | | 著者 | Trillo-Muyo, S, Jasilionis, A, Domagalski, M.J, Chruszcz, M, Minor, W, Kuisiene, N, Arolas, J.L, Sola, M, Gomis-Ruth, F.X. | | 登録日 | 2012-10-03 | | 公開日 | 2012-11-14 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Ultratight crystal packing of a 10 kDa protein.
Acta Crystallogr.,Sect.D, 69, 2013
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