4GTT

Engineered RabGGTase in complex with BMS analogue 12

Summary for 4GTT

Entry DOI	10.2210/pdb4gtt/pdb
Related	4GTM 4GTO 4GTP 4GTQ 4GTR 4GTS 4GTV
Descriptor	Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ... (6 entities in total)
Functional Keywords	protein prenylation, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	75846.69
Authors	Guo, Z.,Stigter, E.A.,Bon, R.S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2012-08-29, release date: 2012-10-24, Last modification date: 2023-11-08)
Primary citation	Stigter, E.A.,Guo, Z.,Bon, R.S.,Wu, Y.W.,Choidas, A.,Wolf, A.,Menninger, S.,Waldmann, H.,Blankenfeldt, W.,Goody, R.S. Development of Selective, Potent RabGGTase Inhibitors J.Med.Chem., 55:8330-8340, 2012 Cited by PubMed: 22963166 DOI: 10.1021/jm300624s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation