4GTT
Engineered RabGGTase in complex with BMS analogue 12
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Geranylgeranyl transferase type-2 subunit alpha | polymer | 330 | 38303.5 | 1 | UniProt (Q08602) Pfam (PF01239) In PDB | Rattus norvegicus (rat) | Geranylgeranyl transferase type II subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab GG transferase alpha, Rab GGTase alpha, Rab geranylgeranyltransferase subunit alpha |
2 | B | Geranylgeranyl transferase type-2 subunit beta | polymer | 330 | 36761.0 | 1 | UniProt (Q08603) Pfam (PF00432) In PDB | Rattus norvegicus (rat) | Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta, Rab geranylgeranyltransferase subunit beta, Type II protein geranyl-geranyltransferase subunit beta |
3 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | B | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
5 | B | 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate | non-polymer | 676.8 | 1 | Chemie (7TQ) | |||
6 | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A: 1 - 237 (UniProt: Q08602)
A: 242 - 330 (UniProt: Q08602)
A: 242 - 330 (UniProt: Q08602)
PDB | External Database | Details |
---|---|---|
Ala 238 | - | linker |
Gly 239 | - | linker |
Ser 240 | - | linker |
Gly 241 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75064.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 782.3 | |
All* | Total formula weight | 75846.7 |