8F3G
 
 | | Crystal structure of Penicillin Binding Protein 5 (PBP5) T485M variant in the penicillin bound form from Enterococcus faecium | | 分子名称: | OPEN FORM - PENICILLIN G, Penicillin binding protein 5, SULFATE ION | | 著者 | D'Andrea, E.D, Choy, M.S, Schoenle, M.V, Page, R, Peti, W. | | 登録日 | 2022-11-10 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | | 主引用文献 | The Molecular Basis for Resistance of E. faecium PBP5 to beta-lactam Antibiotics
Nat Commun, 2023
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8F3Q
 | | Crystal structure of Penicillin Binding Protein 5 (PBP5) Y460A variant apo form from Enterococcus faecium | | 分子名称: | Penicillin binding protein 5, SULFATE ION | | 著者 | D'Andrea, E.D, Schoenle, M.V, Choy, M.S, Page, R, Peti, W. | | 登録日 | 2022-11-10 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The Molecular Basis for Resistance of E. faecium PBP5 to beta-lactam Antibiotics
Nat Commun, 2023
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6N9U
 | | Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) interacting with primase domains of two gp4 subunits bound to an RNA/DNA hybrid and dTTP (from LagS1) | | 分子名称: | DNA (44-MER), DNA primase/helicase, DNA-directed DNA polymerase, ... | | 著者 | Gao, Y, Fox, T, Val, N, Yang, W. | | 登録日 | 2018-12-04 | | 公開日 | 2019-03-06 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structures and operating principles of the replisome.
Science, 363, 2019
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6MH8
 | | High-viscosity injector-based Pink Beam Serial Crystallography of Micro-crystals at a Synchrotron Radiation Source | | 分子名称: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a, Soluble cytochrome b562 chimeric construct | | 著者 | Martin-Garcia, J.M, Zhu, L, Mendez, D, Lee, M, Chun, E, Li, C, Hu, H, Subramanian, G, Kissick, D, Ogata, C, Henning, R, Ishchenko, A, Dobson, Z, Zhan, S, Weierstall, U, Spence, J.C.H, Fromme, P, Zatsepin, N.A, Fischetti, R.F, Cherezov, V, Liu, W. | | 登録日 | 2018-09-17 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source.
Iucrj, 6, 2019
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5KFG
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5KFR
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5KG4
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6MKI
 | | Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the ceftaroline-bound form | | 分子名称: | Ceftaroline, bound form, GLYCEROL, ... | | 著者 | D'Andrea, E.D, Moon, T.M, Peti, W, Page, R. | | 登録日 | 2018-09-25 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.984 Å) | | 主引用文献 | The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance.
J. Biol. Chem., 293, 2018
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8K5A
 | | The cryo-EM map of open TIEA-TIC complex | | 分子名称: | 15 kDa RNA polymerase-binding protein, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, K.N, Liu, Y, Chen, M, Wang, Y, Lin, W, Li, M, Zhang, X, Gao, Y, Gong, Q, Chen, H, Steve, M, Li, S, Zhang, K, Liu, B. | | 登録日 | 2023-07-21 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | TIEA inhibits sigma70-dependent transcriptions, accelerates elongation speed and elevates transcription error
To Be Published
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8K0X
 | | ABCG25 Wild Type purified with DDM in the ABA-bound state | | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ABC transporter G family member 25 | | 著者 | Sun, L, Liu, X, Ying, W, Liao, L, Wei, H. | | 登録日 | 2023-07-10 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | ABCG25 Wild Type purified with DDM in the ABA-bound state
To Be Published
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8K0Z
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8HI8
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6MTG
 | | A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure | | 分子名称: | DI(HYDROXYETHYL)ETHER, FORMIC ACID, GLYCEROL, ... | | 著者 | Li, J.C, Nasertorabi, F, Xuan, W, Han, G.W, Stevens, R.C, Schultz, P.G. | | 登録日 | 2018-10-19 | | 公開日 | 2019-06-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.
Acs Chem.Biol., 14, 2019
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8HCI
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8HI7
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5CB5
 | | Structural Insights into the Mechanism of Escherichia coli Ymdb | | 分子名称: | ACETATE ION, ADENOSINE-5-DIPHOSPHORIBOSE, O-acetyl-ADP-ribose deacetylase, ... | | 著者 | Zhang, W, Wang, C, Song, Y, Shao, C, Zhang, X, Zang, J. | | 登録日 | 2015-06-30 | | 公開日 | 2015-11-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural insights into the mechanism of Escherichia coli YmdB: A 2'-O-acetyl-ADP-ribose deacetylase
J.Struct.Biol., 192, 2015
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5K4I
 | | Crystal Structure of ERK2 in complex with compound 22 | | 分子名称: | 1,2-ETHANEDIOL, 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one, Mitogen-activated protein kinase 1 | | 著者 | Yin, J, Wang, W. | | 登録日 | 2016-05-20 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.
J.Med.Chem., 59, 2016
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5K6S
 | | The structure of the PP2A B56 subunit BubR1 complex | | 分子名称: | BubR1, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | | 著者 | Page, R, Wang, X, Bajaj, R, Peti, W. | | 登録日 | 2016-05-25 | | 公開日 | 2016-12-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | | 主引用文献 | Expanding the PP2A Interactome by Defining a B56-Specific SLiM.
Structure, 24, 2016
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5K7Z
 | | Crystal structure of AibR in complex with isovaleryl coenzyme A and operator DNA | | 分子名称: | DNA (32-MER), Isovaleryl-coenzyme A, Transcriptional regulator, ... | | 著者 | Bock, T, Volz, C, Mueller, R, Blankenfeldt, W. | | 登録日 | 2016-05-27 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Crystal structure of AibR in complex with isovaleryl coenzyme A and operator DNA
to be published
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5KG6
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8U45
 | | Crystal Structure Analysis of Aspergillus fumigatus alkaline protease | | 分子名称: | Alkaline protease 1, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. | | 登録日 | 2023-09-08 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.
Sci Rep, 13, 2023
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8TWI
 | | Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body | | 分子名称: | FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | 著者 | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | | 登録日 | 2023-08-21 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
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5JPE
 | | Yeast-specific serine/threonine protein phosphatase (PPZ1) of Candida albicans | | 分子名称: | CITRATE ANION, GLYCEROL, Serine/threonine-protein phosphatase | | 著者 | Choy, M.S, Chen, E.H, Peti, W, Page, R. | | 登録日 | 2016-05-03 | | 公開日 | 2016-08-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.611 Å) | | 主引用文献 | Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans.
Mbio, 7, 2016
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8TWE
 | | Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body | | 分子名称: | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | 著者 | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | | 登録日 | 2023-08-21 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
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8TTB
 | | Cryo-EM structure of the PP2A:B55-ARPP19 complex | | 分子名称: | FE (III) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | 著者 | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | | 登録日 | 2023-08-13 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
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