6MTG

A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure

Summary for 6MTG

DescriptorHomoserine O-succinyltransferase, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... (5 entities in total)
Functional Keywordsnoncanonical amino acid, isothiocyanate, crosslink, thiourea, stabilization, transferase
Biological sourceEscherichia coli (strain K12)
Total number of polymer chains2
Total molecular weight70703.12
Authors
Li, J.C.,Nasertorabi, F.,Xuan, W.,Han, G.W.,Stevens, R.C.,Schultz, P.G. (deposition date: 2018-10-19, release date: 2019-06-26, Last modification date: 2019-07-10)
Primary citation
Li, J.C.,Nastertorabi, F.,Xuan, W.,Han, G.W.,Stevens, R.C.,Schultz, P.G.
A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.
Acs Chem.Biol., 14:1150-1153, 2019
PubMed: 31181898 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.9b00002
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2224 0.2% 0.6% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report