6MTG
A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008899 | molecular_function | homoserine O-succinyltransferase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0019281 | biological_process | L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008899 | molecular_function | homoserine O-succinyltransferase activity |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0019281 | biological_process | L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 401 |
| Chain | Residue |
| A | ALA82 |
| A | HOH561 |
| B | LEU152 |
| B | TYR153 |
| B | GLY154 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue PEG A 402 |
| Chain | Residue |
| A | HOH548 |
| A | HOH564 |
| A | HOH704 |
| B | ARG56 |
| B | SER59 |
| B | ASN60 |
| B | HOH604 |
| A | GLU18 |
| A | VAL20 |
| A | HIS176 |
| A | ARG181 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 403 |
| Chain | Residue |
| A | ALA177 |
| A | LEU178 |
| A | LEU179 |
| A | TYR292 |
| A | HOH624 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 404 |
| Chain | Residue |
| A | LEU255 |
| A | ASP256 |
| A | HOH513 |
| B | LYS47 |
| B | ARG78 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| B | LEU173 |
| B | HIS174 |
| B | GLU209 |
| B | ILE210 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 402 |
| Chain | Residue |
| B | ALA177 |
| B | LEU178 |
| B | LEU179 |
| B | TYR292 |
| B | HOH555 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 403 |
| Chain | Residue |
| B | GLY107 |
| B | ALA108 |
| B | CSD142 |
| B | TRP143 |
| B | HIS235 |
| B | HOH591 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 404 |
| Chain | Residue |
| A | GLN158 |
| B | GLU8 |
| B | ASP117 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00295","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10572016","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17302437","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17442255","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00295","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17302437","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17442255","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00295","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17302437","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17442255","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00295","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for acyl-CoA specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_00295","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_00295","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
