4XBF
 
 | | Structure of LSD1:CoREST in complex with ssRNA | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | | Authors: | Luka, Z, Loukachevitch, L.V, Martin, W.J, Wagner, C, Reiter, N.J. | | Deposit date: | 2014-12-16 | | Release date: | 2016-04-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.803 Å) | | Cite: | G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme.
RNA, 22, 2016
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1DSI
 | | Solution structure of a duocarmycin sa-indole-alkylated dna dupleX | | Descriptor: | 4-HYDROXY-6-(1H-INDOLE-2-CARBONYL)-8-METHYL-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER, DNA (5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3') | | Authors: | Schnell, J.R, Ketchem, R.R, Boger, D.L, Chazin, W.J. | | Deposit date: | 1998-07-29 | | Release date: | 1998-08-05 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct
J.Am.Chem.Soc., 121, 1999
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7JRH
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7JSJ
 | | Structure of the NaCT-PF2 complex | | Descriptor: | (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | | Deposit date: | 2020-08-14 | | Release date: | 2021-02-24 | | Last modified: | 2021-03-10 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
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7JSK
 | | Structure of the NaCT-Citrate complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, SODIUM ION, ... | | Authors: | Sauer, D.B, Wang, B, Song, J, Rice, W.J, Wang, D.N. | | Deposit date: | 2020-08-14 | | Release date: | 2021-02-24 | | Last modified: | 2021-03-10 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structure and inhibition mechanism of the human citrate transporter NaCT.
Nature, 591, 2021
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2AAK
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1EIS
 | | UDA UNCOMPLEXED FORM. CRYSTAL STRUCTURE OF URTICA DIOICA AGGLUTININ, A SUPERANTIGEN PRESENTED BY MHC MOLECULES OF CLASS I AND CLASS II | | Descriptor: | PROTEIN (AGGLUTININ ISOLECTIN VI/AGGLUTININ ISOLECTIN V) | | Authors: | Saul, F.A, Rovira, P, Boulot, G, Van Damme, E.J.M, Peumans, W.J, Truffa-Bachi, P, Bentley, G.A. | | Deposit date: | 2000-02-28 | | Release date: | 2000-06-21 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Crystal structure of Urtica dioica agglutinin, a superantigen presented by MHC molecules of class I and class II.
Structure Fold.Des., 8, 2000
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1ENM
 | | UDA TRISACCHARIDE COMPLEX. CRYSTAL STRUCTURE OF URTICA DIOICA AGGLUTININ, A SUPERANTIGEN PRESENTED BY MHC MOLECULES OF CLASS I AND CLASS II | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AGGLUTININ ISOLECTIN I/AGGLUTININ ISOLECTIN V/ AGGLUTININ ISOLECTIN VI | | Authors: | Saul, F.A, Rovira, P, Boulot, G, Van Damme, E.J.M, Peumans, W.J, Truffa-Bachi, P, Bentley, G.A. | | Deposit date: | 2000-03-21 | | Release date: | 2000-06-21 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of Urtica dioica agglutinin, a superantigen presented by MHC molecules of class I and class II.
Structure Fold.Des., 8, 2000
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1EN2
 | | UDA TETRASACCHARIDE COMPLEX. CRYSTAL STRUCTURE OF URTICA DIOICA AGGLUTININ, A SUPERANTIGEN PRESENTED BY MHC MOLECULES OF CLASS I AND CLASS II | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AGGLUTININ ISOLECTIN I/AGGLUTININ ISOLECTIN V/ AGGLUTININ ISOLECTIN VI | | Authors: | Saul, F.A, Rovira, P, Boulot, G, Van Damme, E.J.M, Peumans, W.J, Truffa-Bachi, P, Bentley, G.A. | | Deposit date: | 2000-03-20 | | Release date: | 2000-06-21 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure of Urtica dioica agglutinin, a superantigen presented by MHC molecules of class I and class II.
Structure Fold.Des., 8, 2000
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1FNZ
 | | A bark lectin from robinia pseudoacacia in complex with N-acetylgalactosamine | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, BARK AGGLUTININ I, POLYPEPTIDE A, ... | | Authors: | Rabijns, A, Verboven, C, Rouge, P, Barre, A, Van Damme, E.J, Peumans, W.J, De Ranter, C.J. | | Deposit date: | 2000-08-24 | | Release date: | 2001-08-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure of a legume lectin from the bark of Robinia pseudoacacia and its complex with N-acetylgalactosamine
Proteins, 44, 2001
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1FNY
 | | LEGUME LECTIN OF THE BARK OF ROBINIA PSEUDOACACIA. | | Descriptor: | BARK AGGLUTININ I,POLYPEPTIDE A, CALCIUM ION | | Authors: | Rabijns, A, Verboven, C, Rouge, P, Barre, A, Van Damme, E.J, Peumans, W.J, De Ranter, C.J. | | Deposit date: | 2000-08-24 | | Release date: | 2001-08-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Structure of a legume lectin from the bark of Robinia pseudoacacia and its complex with N-acetylgalactosamine.
Proteins, 44, 2001
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7LMW
 | | Receptor for Advanced Glycation End Products VC1 domain in complex with 3-(3-((4-(4-carboxyphenoxy)benzyl)oxy)phenyl)-1H-indole-2-carboxylic acid | | Descriptor: | 7-methyl-3-(1~{H}-pyrazol-4-yl)-1~{H}-indole-2-carboxylic acid, ACETATE ION, Advanced glycosylation end product-specific receptor, ... | | Authors: | Salay, L.E, Kozlyuk, N, Gilston, B.A, Gogliotti, R.D, Christov, P.P, Kim, K, Ovee, M, Waterson, A.G, Chazin, W.J. | | Deposit date: | 2021-02-06 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Proteins, 89, 2021
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6HNK
 | | The ligand-free, open structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile. | | Descriptor: | ABC-type transport system, sugar-family extracellular solute-binding protein | | Authors: | Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R. | | Deposit date: | 2018-09-15 | | Release date: | 2019-08-28 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
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7LML
 | | Receptor for Advanced Glycation End Products VC1 domain in complex with 3-(3-(((3-(4-Carboxyphenoxy)benzyl)oxy)methyl)phenyl)-1H-indole-2-carboxylic acid | | Descriptor: | 6-iodanyl-1~{H}-indole-2-carboxylic acid, ACETATE ION, Advanced glycosylation end product-specific receptor, ... | | Authors: | Salay, L.E, Kozlyuk, N, Gilston, B.A, Gogliotti, R.D, Christov, P.P, Kim, K, Ovee, M, Waterson, A.G, Chazin, W.J. | | Deposit date: | 2021-02-05 | | Release date: | 2021-12-15 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors.
Proteins, 89, 2021
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6HNJ
 | | The ligand-bound, open structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile. | | Descriptor: | 1,2-ETHANEDIOL, ABC-type transport system, sugar-family extracellular solute-binding protein, ... | | Authors: | Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R. | | Deposit date: | 2018-09-15 | | Release date: | 2019-08-28 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
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6HNI
 | | The ligand-bound, closed structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile. | | Descriptor: | 1,2-ETHANEDIOL, ABC-type transport system, sugar-family extracellular solute-binding protein, ... | | Authors: | Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R. | | Deposit date: | 2018-09-15 | | Release date: | 2019-08-28 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
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6HH1
 | | Structure of c-Kit with allosteric inhibitor 3G8 | | Descriptor: | Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, PHOSPHATE ION, ~{N}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{H}-1,2,4-triazol-3-amine | | Authors: | Wrasidlo, W.J, Cheresh, D.A. | | Deposit date: | 2018-08-24 | | Release date: | 2019-09-18 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of c-Kit with allosteric inhibitor 3G8
To Be Published
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6HQ9
 | | Crystal structure of the Tudor domain of human ERCC6-L2 | | Descriptor: | DNA excision repair protein ERCC-6-like 2 | | Authors: | Newman, J.A, Gavard, A.E, Nathan, W.J, Pinkas, D.M, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | Deposit date: | 2018-09-24 | | Release date: | 2018-10-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.982 Å) | | Cite: | Crystal structure of the Tudor domain of human ERCC6-L2
To Be Published
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6IPJ
 | | Binary Complex of Human DNA Polymerase Mu with MndTTP | | Descriptor: | DNA-directed DNA/RNA polymerase mu,DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, SULFATE ION, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-11-03 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6IEX
 | | Crystal structure of HLA-B*4001 in complex with SARS-CoV derived peptide N216-225 GETALALLLL | | Descriptor: | Beta-2-microglobulin, GLY-GLU-THR-ALA-LEU-ALA-LEU-LEU-LEU-LEU, MHC class I antigen | | Authors: | Ji, W, Niu, L, Peng, W, Zhang, Y, Shi, Y, Qi, J, Gao, G.F, Liu, W.J. | | Deposit date: | 2018-09-17 | | Release date: | 2019-09-18 | | Last modified: | 2021-03-31 | | Method: | X-RAY DIFFRACTION (2.314 Å) | | Cite: | Salt bridge-forming residues positioned over viral peptides presented by MHC class I impacts T-cell recognition in a binding-dependent manner.
Mol.Immunol., 112, 2019
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6IPG
 | | Post-catalytic Complex of Human DNA Polymerase Mu with Templating Cytosine and Mg-8oxodGMP | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*CP*TP*AP*CP*G)-3'), ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-11-03 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6IPN
 | | Binary Complex of Human DNA Polymerase Mu with MgdGTP | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MAGNESIUM ION, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-11-03 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6IBE
 | | The FERM domain of Human EPB41L3 | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Band 4.1-like protein 3 | | Authors: | Bradshaw, W.J, Katis, V.L, Newman, J.A, Fernandez-Cid, A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | Deposit date: | 2018-11-29 | | Release date: | 2018-12-19 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The FERM domain of Human EPB41L3
To Be Published
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6IPH
 | | Binary Complex of Human DNA Polymerase Mu with MndATP | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... | | Authors: | Chang, Y.K, Wu, W.J, Tsai, M.D. | | Deposit date: | 2018-11-03 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6IBD
 | | The Phosphatase and C2 domains of Human SHIP1 | | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | | Authors: | Bradshaw, W.J, Williams, E.P, Fernandez-Cid, A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | | Deposit date: | 2018-11-29 | | Release date: | 2019-01-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
Structure, 2024
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