Structure of LSD1:CoREST in complex with ssRNA

Summary for 4XBF

DescriptorLysine-specific histone demethylase 1A, REST corepressor 1, RNA (5'-R(*UP*UP*AP*GP*G)-3'), ... (7 entities in total)
Functional Keywordslsd1, lysine specific demethylase, demethylase, demethylation, rna, corest, rest co-repressor 1, amine oxidase, coiled-coil, swirm, chromatin remodelling enzyme, epigenetics, histone modifying enzyme, non-coding rna, ncrna, kdm1a, oxidoreductase-transcription-rna complex, oxidoreductase/transcription/rna
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  O60341 Q9UKL0
Total number of polymer chains3
Total molecular weight92389.17
Luka, Z.,Loukachevitch, L.V.,Martin, W.J.,Wagner, C.,Reiter, N.J. (deposition date: 2014-12-16, release date: 2016-04-27, Last modification date: 2017-05-03)
Primary citation
Hirschi, A.,Martin, W.J.,Luka, Z.,Loukachevitch, L.V.,Reiter, N.J.
G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme.
RNA, 22:1250-1260, 2016
PubMed: 27277658 (PDB entries with the same primary citation)
DOI: 10.1261/rna.057265.116
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.229200.1%3.2%0.31MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report