6X5P

Discovery of Hydroxy Pyrimidine Factor IXa Inhibitors

Summary for 6X5P

Entry DOI	10.2210/pdb6x5p/pdb
Related	6X5J 6X5L
Descriptor	Coagulation factor IX, 3-chloro-4-{[5-hydroxy-6-(4-methylphenyl)pyrimidin-4-yl]amino}benzene-1-carboximidamide, CITRIC ACID, ... (6 entities in total)
Functional Keywords	serine protease, zymogen, hydrolase, glycoprotein, hydroxylation, phosphoprotein, sulfation, hemostasis, hemophilia, xase-like variant, communication channel, gamma-carboxyglutamic acid, egf-like domain, disease mutation, blood clotting
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	34253.00
Authors	Jayne, C.L.,Andreani, T.,Chan, T.,Chelliah, M.V.,Clasby, M.C.,Dwyer, M.,Eagen, K.A.,Fried, S.,Greenlee, W.J.,Guo, Z.,Hawes, B.,Hruza, A.,Ingram, R.,Keertikar, K.M.,Neelamkavil, S.,Reichert, P.,Xia, Y.,Chackalamannil, S. (deposition date: 2020-05-26, release date: 2020-06-24)
Primary citation	Jayne, C.L.,Andreani, T.,Chan, T.Y.,Chelliah, M.V.,Clasby, M.C.,Dwyer, M.,Eagen, K.A.,Fried, S.,Greenlee, W.J.,Guo, Z.,Hawes, B.,Hruza, A.,Ingram, R.,Keertikar, K.M.,Neelamkavil, S.,Reichert, P.,Xia, Y.,Chackalamannil, S. Discovery of hydroxy pyrimidine Factor IXa inhibitors. Bioorg.Med.Chem.Lett., 30:127279-127279, 2020 Cited by PubMed: 32527459 DOI: 10.1016/j.bmcl.2020.127279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.997 Å)

Structure validation