5M8T
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![BU of 5m8t by Molmil](/molmil-images/mine/5m8t) | Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone | Descriptor: | 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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8Q7M
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8EKG
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![BU of 8ekg by Molmil](/molmil-images/mine/8ekg) | MHETase variant Thr159Val, Met192Tyr, Tyr252Phe, Tyr503Trp | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Saunders, J.W, Frkic, R.L, Jackson, C.J. | Deposit date: | 2022-09-20 | Release date: | 2023-10-18 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design. Biochemistry, 63, 2024
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8Q8D
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8Q2J
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![BU of 8q2j by Molmil](/molmil-images/mine/8q2j) | Tau - AD-MIA2 | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | Authors: | Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-08-02 | Release date: | 2023-08-30 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (2.23 Å) | Cite: | Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
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8Q7F
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![BU of 8q7f by Molmil](/molmil-images/mine/8q7f) | Tau - AD-MIA5 | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | Authors: | Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-08-16 | Release date: | 2023-08-30 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
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5MA2
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![BU of 5ma2 by Molmil](/molmil-images/mine/5ma2) | PCE reductive dehalogenase from S. multivorans in complex with 4-iodophenol | Descriptor: | 4-IODOPHENOL, BENZAMIDINE, GLYCEROL, ... | Authors: | Kunze, C, Bommer, M, Hagen, W.R, Uksa, M, Dobbek, H, Schubert, T, Diekert, G. | Deposit date: | 2016-11-03 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.879 Å) | Cite: | Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer. Nat Commun, 8, 2017
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8Q8C
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3QRK
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![BU of 3qrk by Molmil](/molmil-images/mine/3qrk) | The crystal structure of human abl1 kinase domain in complex with DP-987 | Descriptor: | (3S)-6-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, Tyrosine-protein kinase ABL1 | Authors: | Chan, W.W, Wise, S.C, Kaufman, M.D, Ahn, Y.M, Ensinger, C.L, Haack, T, Hood, M.M, Jones, J, Lord, J.W, Lu, W.P, Miller, D, Patt, W.C, Smith, B.D, Petillo, P.A, Rutkoski, T.J, Telikepalli, H, Vogeti, L, Yao, T, Chun, L, Clark, R, Evangelista, P, Gavrilescu, L.C, Lazarides, K, Zaleskas, V.M, Stewart, L.J, Van Etten, R.A, Flynn, D.L. | Deposit date: | 2011-02-18 | Release date: | 2011-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036. Cancer Cell, 19, 2011
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8Q27
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![BU of 8q27 by Molmil](/molmil-images/mine/8q27) | Tau: AD-MIA1 | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | Authors: | Lovestam, S, Scheres, S.H.W, Goedert, M, Li, D. | Deposit date: | 2023-08-01 | Release date: | 2023-08-30 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (2.02 Å) | Cite: | Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
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8Q9F
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8Q9G
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8Q9J
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8Q9K
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4LUO
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![BU of 4luo by Molmil](/molmil-images/mine/4luo) | Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions | Descriptor: | 1-(3-methylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit | Authors: | Feldkamp, M.D, Frank, A.O, Kennedy, J.P, Waterson, A.G, Olejniczak, E.T, Pelz, N.F, Patrone, J.D, Vangamudi, B, Camper, D.V, Rossanese, O.W, Fesik, S.W, Chazin, W.J. | Deposit date: | 2013-07-25 | Release date: | 2013-12-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J.Med.Chem., 56, 2013
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8Q9M
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4M9X
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![BU of 4m9x by Molmil](/molmil-images/mine/4m9x) | Crystal structure of CED-4 bound CED-3 fragment | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | Authors: | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | Deposit date: | 2013-08-15 | Release date: | 2013-10-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.344 Å) | Cite: | Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev., 27, 2013
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8Q9L
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4XJV
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![BU of 4xjv by Molmil](/molmil-images/mine/4xjv) | Crystal structure of human thioesterase 2 | Descriptor: | CHLORIDE ION, S-acyl fatty acid synthase thioesterase, medium chain | Authors: | Ritchie, M.K, Kridel, S.J, Lowther, W.T. | Deposit date: | 2015-01-09 | Release date: | 2015-12-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. J.Biol.Chem., 291, 2016
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8Q9I
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8Q9O
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8Q7L
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8QCP
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8Q88
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5XH3
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![BU of 5xh3 by Molmil](/molmil-images/mine/5xh3) | Crystal structure of a novel PET hydrolase R103G/S131A mutant in complex with HEMT from Ideonella sakaiensis 201-F6 | Descriptor: | GLYCEROL, O 4-(2-hydroxyethyl) O 1-methyl benzene-1,4-dicarboxylate, Poly(ethylene terephthalate) hydrolase, ... | Authors: | Han, X, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | Deposit date: | 2017-04-19 | Release date: | 2017-12-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural insight into catalytic mechanism of PET hydrolase Nat Commun, 8, 2017
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