8Q7M

Tau - AD-MIA7 (tau intermediate amyloid)

Summary for 8Q7M

Entry DOI	10.2210/pdb8q7m/pdb
EMDB information	18224
Descriptor	Isoform Tau-D of Microtubule-associated protein tau (1 entity in total)
Functional Keywords	amyloid, tau, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	9
Total formula weight	360024.96
Authors	Lovestam, S.,Li, D.,Scheres, S.H.W.,Goedert, M. (deposition date: 2023-08-16, release date: 2023-08-30, Last modification date: 2024-01-24)
Primary citation	Lovestam, S.,Li, D.,Wagstaff, J.L.,Kotecha, A.,Kimanius, D.,McLaughlin, S.H.,Murzin, A.G.,Freund, S.M.V.,Goedert, M.,Scheres, S.H.W. Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625:119-125, 2024 Cited by PubMed: 38030728 DOI: 10.1038/s41586-023-06788-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.26 Å)

Structure validation