8Q8C

Tau - AD-MIA10 (intermediate amyloid)

Summary for 8Q8C

Entry DOI	10.2210/pdb8q8c/pdb
EMDB information	18250
Descriptor	Isoform Tau-D of Microtubule-associated protein tau (1 entity in total)
Functional Keywords	amyloid, tau, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	240016.64
Authors	Lovestam, S.,Li, D.,Scheres, S.H.W.,Goedert, M. (deposition date: 2023-08-18, release date: 2023-09-06, Last modification date: 2024-01-24)
Primary citation	Lovestam, S.,Li, D.,Wagstaff, J.L.,Kotecha, A.,Kimanius, D.,McLaughlin, S.H.,Murzin, A.G.,Freund, S.M.V.,Goedert, M.,Scheres, S.H.W. Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625:119-125, 2024 Cited by PubMed: 38030728 DOI: 10.1038/s41586-023-06788-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (1.92 Å)

Structure validation