1SE0
 
 | | Crystal structure of DIAP1 BIR1 bound to a Grim peptide | | Descriptor: | Apoptosis 1 inhibitor, Cell death protein Grim, ZINC ION | | Authors: | Yan, N, Wu, J.W, Shi, Y. | | Deposit date: | 2004-02-15 | | Release date: | 2004-04-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.
Nat.Struct.Mol.Biol., 11, 2004
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3F1L
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5B80
 | | Crystal Structure of Hyperthermophilic Thermotoga maritima L-Ketose-3-Epimerase with Cu2+ | | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, COPPER (II) ION, Uncharacterized protein TM_0416 | | Authors: | Cao, T.P, Shin, S.M, Lee, D.W, Lee, S.H. | | Deposit date: | 2016-06-10 | | Release date: | 2017-03-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | TM0416, a Hyperthermophilic Promiscuous Nonphosphorylated Sugar Isomerase, Catalyzes Various C5and C6Epimerization Reactions
Appl. Environ. Microbiol., 83, 2017
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5EMG
 | | Crystal structures of PNA p(GCTGCTGC)2 duplex containing T-T mismatches | | Descriptor: | CHLORIDE ION, GPN-CPN-TPN-GPN-CPN-TPN-GPN-CPN, SODIUM ION | | Authors: | Kiliszek, A, Banaszak, K, Dauter, Z, Rypniewski, W. | | Deposit date: | 2015-11-06 | | Release date: | 2016-01-13 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches-toward anti-sense therapy against TREDs.
Nucleic Acids Res., 44, 2016
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7EEW
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1F04
 | | SOLUTION STRUCTURE OF OXIDIZED BOVINE MICROSOMAL CYTOCHROME B5 MUTANT (E44A, E48A, E56A, D60A) AND ITS INTERACTION WITH CYTOCHROME C | | Descriptor: | CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Wu, Y.B, Lu, J, Qian, C.M, Tang, W.X, Li, E.C, Wang, J.F, Wang, Y.H, Wang, W.H, Lu, J.X, Xie, Y, Huang, Z.X. | | Deposit date: | 2000-05-14 | | Release date: | 2000-06-21 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of cytochrome b(5) mutant (E44/48/56A/D60A) and its interaction with cytochrome c.
Eur.J.Biochem., 268, 2001
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1BCC
 | | CYTOCHROME BC1 COMPLEX FROM CHICKEN | | Descriptor: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, FE2/S2 (INORGANIC) CLUSTER, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Zhang, Z, Huang, L, Shulmeister, V.M, Chi, Y.-I, Kim, K.K, Hung, L.-W, Crofts, A.R, Berry, E.A, Kim, S.-H. | | Deposit date: | 1998-03-23 | | Release date: | 1998-08-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.16 Å) | | Cite: | Electron transfer by domain movement in cytochrome bc1.
Nature, 392, 1998
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8SIC
 | | Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cy137C02 Fab heavy chain, Cy137C02 Fab light chain, ... | | Authors: | Joyce, M.G, Jensen, J.L, Chen, W.H, Kanekiyo, M. | | Deposit date: | 2023-04-14 | | Release date: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine
To Be Published
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7EHW
 | | BRD4-BD1 in complex with LT-642-602 | | Descriptor: | 1-[4-ethyl-2-methyl-5-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | | Deposit date: | 2021-03-30 | | Release date: | 2022-03-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | BRD4-BD1 in complex with LT-642-602
To Be Published
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6ALI
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7EHY
 | | BRD4-BD1 in complex with LT-448-138 | | Descriptor: | 1-[2,4-dimethyl-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | | Deposit date: | 2021-03-30 | | Release date: | 2022-03-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | BRD4-BD1 in complex with LT-642-602
To Be Published
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7EIG
 | | BRD4-BD1 in complex with LT-730-903 | | Descriptor: | 1-[5-(5-azanyl-1H-benzimidazol-2-yl)-2-methyl-4-phenyl-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | | Deposit date: | 2021-03-31 | | Release date: | 2022-04-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | BRD4-BD1 in complex with LT-730-903
To Be Published
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6AEO
 | | TssL periplasmic domain | | Descriptor: | GLYCEROL, Maltose/maltodextrin-binding periplasmic protein,TssL | | Authors: | Ran, T.T, Wang, W.W, Wang, X.B, Xu, D.Q. | | Deposit date: | 2018-08-06 | | Release date: | 2019-06-12 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the periplasmic domain of TssL, a key membrane component of Type VI secretion system.
Int.J.Biol.Macromol., 120, 2018
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7T2X
 | | Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 2-chloro-4-((4-hydroxybenzyl)amino)-5-phenylthieno[2,3-d]pyrimidin-6-ol and GRIP Peptide | | Descriptor: | Estrogen receptor, Nuclear receptor coactivator 2, S-(2-chloro-6-{[(4-hydroxyphenyl)methyl]amino}pyrimidin-4-yl) phenylethanethioate | | Authors: | Joiner, C, Sammeta, V.K.R, Norris, J.D, McDonnell, D.P, Wilson, T.M, Fanning, S.W. | | Deposit date: | 2021-12-06 | | Release date: | 2022-06-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3- d ]pyrimidine Core.
Acs Med.Chem.Lett., 13, 2022
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1BG6
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1NWI
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1BEU
 | | TRP SYNTHASE (D60N-IPP-SER) WITH K+ | | Descriptor: | INDOLE-3-PROPANOL PHOSPHATE, POTASSIUM ION, TRYPTOPHAN SYNTHASE, ... | | Authors: | Rhee, S, Mozzarelli, A, Miles, E.W, Davies, D.R. | | Deposit date: | 1998-05-18 | | Release date: | 1998-08-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60.
Biochemistry, 37, 1998
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6IXN
 | | Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and citrate | | Descriptor: | CITRATE ANION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Zhu, G.P, Tang, W.G, Wang, P. | | Deposit date: | 2018-12-11 | | Release date: | 2019-12-18 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs.
Arch.Biochem.Biophys., 708, 2021
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7EIK
 | | RD4-BD1 in complex with LT-872-297 | | Descriptor: | 1-[2-methyl-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-4-(1-methylpyrazol-4-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | | Deposit date: | 2021-03-31 | | Release date: | 2022-04-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | RD4-BD1 in complex with LT-872-297
To Be Published
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7SQ1
 | | BG505.MD39TS Env trimer in complex with Fab from antibody C05 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C05 Fab Light chain, ... | | Authors: | Moore, A, Du, J, Xu, Z, Walker, S, Kulp, D.W, Pallesen, J. | | Deposit date: | 2021-11-04 | | Release date: | 2022-06-22 | | Last modified: | 2022-12-07 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer.
Nat Commun, 13, 2022
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8SR9
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium | | Descriptor: | CHOLESTEROL, MAGNESIUM ION, TRPM2 chanzyme | | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | | Deposit date: | 2023-05-05 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 2024
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7EIL
 | | BRD4-BD1 in complex with LT-909-110 | | Descriptor: | Bromodomain-containing protein 4, N-[4-[4-ethanoyl-5-methyl-2-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]phenyl]ethanamide | | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | | Deposit date: | 2021-03-31 | | Release date: | 2022-04-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy
Eur.J.Med.Chem., 227, 2022
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8SRA
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium | | Descriptor: | CALCIUM ION, CHOLESTEROL, TRPM2 chanzyme | | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | | Deposit date: | 2023-05-05 | | Release date: | 2024-05-08 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 2024
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1BIA
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6J29
 | | The structure of HLA-A*3003/MTB | | Descriptor: | Beta-2-microglobulin, HLA-A*3003, MTB | | Authors: | Zhu, S.Y, Liu, K.F, Chai, Y, Ding, C.M, Lv, J.X, Gao, F.G, Lou, Y.L, Liu, W.J. | | Deposit date: | 2018-12-31 | | Release date: | 2019-09-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides.
Front Immunol, 10, 2019
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