7T2X

Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 2-chloro-4-((4-hydroxybenzyl)amino)-5-phenylthieno[2,3-d]pyrimidin-6-ol and GRIP Peptide

Summary for 7T2X

Entry DOI	10.2210/pdb7t2x/pdb
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, S-(2-chloro-6-{[(4-hydroxyphenyl)methyl]amino}pyrimidin-4-yl) phenylethanethioate, ... (4 entities in total)
Functional Keywords	estrogen receptor, hormone agonist, alpha helical bundle, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	63479.71
Authors	Joiner, C.,Sammeta, V.K.R.,Norris, J.D.,McDonnell, D.P.,Wilson, T.M.,Fanning, S.W. (deposition date: 2021-12-06, release date: 2022-06-22, Last modification date: 2023-10-18)
Primary citation	Sammeta, V.R.,Norris, J.D.,Artham, S.,Torrice, C.D.,Byemerwa, J.,Joiner, C.,Fanning, S.W.,McDonnell, D.P.,Willson, T.M. A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3- d ]pyrimidine Core. Acs Med.Chem.Lett., 13:1151-1158, 2022 Cited by PubMed: 35859859 DOI: 10.1021/acsmedchemlett.2c00180 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation