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PDB: 73 件
1NWC
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Crystal Structure of Aspartate-Semialdehyde Dehydrogenase from Haemophilus influenzae
分子名称: Aspartate-semialdehyde dehydrogenase
著者Blanco, J, Moore, R.A, Viola, R.E.
登録日2003-02-05
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Capture of an Intermediate in the Catalytic Cycle of L-Aspartate-beta-Semialdehyde Dehydrogenase
Proc.Natl.Acad.Sci.USA, 100, 2003
1NWH
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Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae as a Tetrahedral Hemithioacetal Reaction Intermediate at 2.0 A
分子名称: Aspartate-semialdehyde dehydrogenase
著者Blanco, J, Moore, R.A, Viola, R.E.
登録日2003-02-06
公開日2003-11-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Capture of an Intermediate in the Catalytic Cycle of L-Aspartate-beta-Semialdehyde Dehydrogenase
Proc.Natl.Acad.Sci.USA, 100, 2003
1MC4
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Crystal Structure of Aspartate-Semialdehyde dehydrogenase from Vibrio Cholerae El Tor
分子名称: Aspartate-semialdehyde dehydrogenase
著者Blanco, J, Moore, R.A, Kabaleeswaran, V, Viola, R.E.
登録日2002-08-05
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献A Structural Basis for the Mechanism of Aspartate-beta-semialdehyde Dehydrogenase from Vibrio Cholerae
Protein Sci., 12, 2003
4R41
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Complex Crystal structure of 4-nitro-2-phosphono-benzoic acid with sp-Aspartate-Semialdehyde Dehydrogenase and Nicotinamide-dinucleotide
分子名称: 1,2-ETHANEDIOL, 4-nitro-2-phosphonobenzoic acid, ACETATE ION, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2014-08-18
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R3N
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BU of 4r3n by Molmil
Crystal structure of the ternary complex of sp-ASADH with NADP and 1,2,3-Benzenetricarboxylic acid
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2014-08-16
公開日2014-12-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R5H
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BU of 4r5h by Molmil
Crystal structure of sp-Aspartate-Semialdehyde-Dehydrogenase with Nicotinamide-Adenine-Dinucleotide-Phosphate and 3-carboxy-propenyl-phthalic acid
分子名称: 1,2-ETHANEDIOL, 3-[(1E)-3-carboxyprop-1-en-1-yl]benzene-1,2-dicarboxylic acid, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E.
登録日2014-08-21
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R3W
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Crystal Structure Analysis of the 1,2,3-tricarboxylate benzoic acid bound to sp-ASADH-2'5'-ADP complex
分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-2'-5'-DIPHOSPHATE, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2014-08-18
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R5M
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Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid
分子名称: 4-nitro-2-phosphonobenzoic acid, Aspartate-semialdehyde dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E.
登録日2014-08-21
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4TNU
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Human brain aspartoacylase mutant Y231C complex with intermediate analog (N-phosphonomethyl-L-aspartate)
分子名称: Aspartoacylase, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ZINC ION
著者Wijayasinghe, Y.S, Pavlovsky, A.G, Viola, R.E.
登録日2014-06-05
公開日2014-07-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Aspartoacylase catalytic deficiency as the cause of canavan disease: a structural perspective.
Biochemistry, 53, 2014
1MB4
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BU of 1mb4 by Molmil
Crystal structure of aspartate semialdehyde dehydrogenase from vibrio cholerae with NADP and S-methyl-l-cysteine sulfoxide
分子名称: Aspartate-Semialdehyde Dehydrogenase, CYSTEINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Blanco, J, Moore, R.A, Kabaleeswaran, V, Viola, R.E.
登録日2002-08-02
公開日2003-01-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献A structural Basis for the Mechanism of Aspartate-beta-semialdehyde Dehydrogenase from Vibrio Cholerae
Protein Sci., 12, 2003
4R4J
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BU of 4r4j by Molmil
Crystal structure of complex sp_ASADH with 3-carboxypropyl-phthalic acid and Nicotinamide Adenine dinucleotide phosphate
分子名称: 1,2-ETHANEDIOL, 3-(3-carboxypropyl)benzene-1,2-dicarboxylic acid, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E.
登録日2014-08-19
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R51
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BU of 4r51 by Molmil
Crystal complex structure of sp-Aspartate-Semialdehyde-Dehydrogenase with Nicotinamide Adenine dinucleotide phosphate and phthalic acid
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2014-08-20
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
4R54
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Complex crystal structure of sp-Aspartate-Semialdehyde-Dehydrogenase with 3-carboxy-ethyl-phthalic acid
分子名称: 3-(2-carboxyethyl)benzene-1,2-dicarboxylic acid, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2014-08-20
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70, 2014
6C8W
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BU of 6c8w by Molmil
Crystal structure of Aspartate Semialdehyde Dehydrogenase with NADP from Blastomyces dermatitidis
分子名称: Aspartate-semialdehyde dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Dahal, G.P, Viola, R.E.
登録日2018-01-25
公開日2019-01-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Biochem.Biophys.Res.Commun., 503, 2018
6C85
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Crystal structure of aspartate semialdehyde dehydrogenase from Blastomyces dermatitidis with p-benzoquinone
分子名称: 1,4-benzoquinone, Aspartate-semialdehyde dehydrogenase
著者Dahal, G.P, Viola, R.E.
登録日2018-01-24
公開日2019-01-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Biochem.Biophys.Res.Commun., 503, 2018
3Q0E
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BU of 3q0e by Molmil
Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Vibrio Cholerae with product of S-allyl-L-cysteine sulfoxide
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Liu, X, Viola, R.E.
登録日2010-12-15
公開日2012-02-22
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural characterization of inhibitors with selectivity against members of a homologous enzyme family.
Chem.Biol.Drug Des., 79, 2012
3Q1L
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Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Streptococcus pneumoniae with cysteamine bound covalently to Cys 128
分子名称: 2-AMINO-ETHANETHIOL, Aspartate beta-semialdehyde dehydrogenase
著者Pavlovsky, A.G, Viola, R.E.
登録日2010-12-17
公開日2012-01-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
3PYL
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BU of 3pyl by Molmil
Crystal structure of aspartate beta-semialdehide dehydrogenase from Streptococcus pneumoniae with D-2,3-diaminopropionate
分子名称: 3-amino-D-alanine, Aspartate-semialdehyde dehydrogenase
著者Pavlovsky, A.G, Liu, X, Faehnle, C.R, Potente, N, Viola, R.E.
登録日2010-12-13
公開日2012-01-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
3PWS
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BU of 3pws by Molmil
Crystal Structure of Aspartate beta-Semialdehide Dehydrogenase from Streptococcus pneumoniae with 2',5'-Adenosine diphosphate and D-2-aminoadipate
分子名称: (2R)-2-aminohexanedioic acid, ADENOSINE-2'-5'-DIPHOSPHATE, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2010-12-08
公開日2012-01-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
3PYX
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BU of 3pyx by Molmil
Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase complex with NADP and 2-aminoterephthalate
分子名称: 1,2-ETHANEDIOL, 2-aminobenzene-1,4-dicarboxylic acid, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2010-12-13
公開日2012-01-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
3PWK
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BU of 3pwk by Molmil
Crystal Structure of Aspartate beta-Semialdehide Dehydrogenase from Streptococcus pneumoniae with 2',5'-Adenosine diphosphate and D-2-aminoadipate
分子名称: 1,2-ETHANEDIOL, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2010-12-08
公開日2012-01-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
3PZR
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Crystals structure of aspartate beta-Semialdehyde dehydrogenase from Vibrio Cholerae with NADP and product of S-carbamoyl-L-cysteine
分子名称: Aspartate-semialdehyde dehydrogenase, CYSTEINE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Pavlovsky, A.G, Potente, N, Viola, R.E.
登録日2010-12-14
公開日2012-01-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
3PZB
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BU of 3pzb by Molmil
Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase complex with NADP and D-2,3-Diaminopropionate
分子名称: 1,2-ETHANEDIOL, 3-amino-D-alanine, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E.
登録日2010-12-14
公開日2012-01-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
3Q11
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Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Streptococcus pneumoniae with NADP and aspartyl beta-difluorophosphonate
分子名称: 1,2-ETHANEDIOL, 5,5-difluoro-4-oxo-5-phosphono-D-norvaline, Aspartate-semialdehyde dehydrogenase, ...
著者Pavlovsky, A.G, Viola, R.E, Faehnle, C.R.
登録日2010-12-16
公開日2012-01-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family.
Chem.Biol.Drug Des., 79, 2012
1PQU
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Crystal Structure of the H277N Mutant of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae Bound with NADP, S-methyl cysteine sulfoxide and cacodylate
分子名称: Aspartate-semialdehyde dehydrogenase, CACODYLATE ION, CYSTEINE, ...
著者Blanco, J, Moore, R.A, Viola, R.E.
登録日2003-06-19
公開日2004-08-10
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004

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件を2024-09-11に公開中

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