4R3N

Crystal structure of the ternary complex of sp-ASADH with NADP and 1,2,3-Benzenetricarboxylic acid

Summary for 4R3N

Entry DOI	10.2210/pdb4r3n/pdb
Descriptor	Aspartate-semialdehyde dehydrogenase, SODIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywords	protein-nadp-ligand complex, dehydrogenase, oxidoreductase, nadp binding
Biological source	Streptococcus pneumoniae
Total number of polymer chains	2
Total formula weight	83343.03
Authors	Pavlovsky, A.G.,Viola, R.E. (deposition date: 2014-08-16, release date: 2014-12-10, Last modification date: 2024-02-28)
Primary citation	Pavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70:3244-3252, 2014 Cited by PubMed: 25478842 DOI: 10.1107/S1399004714023979 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation