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4R3W

Crystal Structure Analysis of the 1,2,3-tricarboxylate benzoic acid bound to sp-ASADH-2'5'-ADP complex

Summary for 4R3W
Entry DOI10.2210/pdb4r3w/pdb
Related4R3N 4R41 4R4J 4R51 4R54 4R5H 4R5M
DescriptorAspartate-semialdehyde dehydrogenase, SODIUM ION, benzene-1,2,3-tricarboxylic acid, ... (7 entities in total)
Functional Keywordsdehydrogenase, nicotineamid-dinucleotide, oxidoreductase
Biological sourceStreptococcus pneumoniae
Total number of polymer chains2
Total formula weight81704.08
Authors
Pavlovsky, A.G.,Viola, R.E. (deposition date: 2014-08-18, release date: 2014-12-10, Last modification date: 2023-09-20)
Primary citationPavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E.
A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 70:3244-3252, 2014
Cited by
PubMed: 25478842
DOI: 10.1107/S1399004714023979
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.91 Å)
Structure validation

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